The voltage-gated sodium channel is essential for nerve cells to function. But how does it work? A low-resolution, three-dimensional structure provides some provocative insights.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 52 print issues and online access
$199.00 per year
only $3.83 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to the full article PDF.
USD 39.95
Prices may be subject to local taxes which are calculated during checkout

DAVID EHLERT

References
Sato, C. et al. Nature 409, 1047–1051 (2001).
Beneski, D. A. & Catterall, W. A. Proc. Natl Acad. Sci. USA 77, 639–642 (1980).
Agnew, W. A., Moore, A. C., Levinson, S. R. & Raftery, M. A. Biochem. Biophys. Res. Commun. 92, 860–866 (1980).
Noda, M. et al. Nature 312, 121–127 (1984).
Goldin, A. L. et al. Neuron 28, 365–368 (2000).
Catterall, W. A. Neuron 26, 13–25 (2000).
Lehmann-Horn, F. & Jurkat-Rott, K. Physiol. Rev. 79, 1317–1372 (1999).
Doyle, D. A. et al. Science 280, 69–77 (1998).
Rohl, C. A., Boeckman, F. A., Scheuer, T., Catterall, W. A. & Klevit, R. Biochemistry 38, 855–861 (1999).
Yang, N., George, A. L. & Horn, R. Neuron 16, 113–122 (1996).
Cha, A., Snyder, G. E., Selvin, P. R. & Bezanilla, F. Nature 402, 809–813 (1999).
Glauner, K. S., Manuzzu, L. M., Gandhi, C. S. & Isacoff, E. Nature 402, 813–817 (1999).
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Catterall, W. A 3D view of sodium channels. Nature 409, 988–991 (2001). https://doi.org/10.1038/35059188
Issue date:
DOI: https://doi.org/10.1038/35059188