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. 1984 Aug 22;222(1227):147-53.
doi: 10.1098/rspb.1984.0055.

On the binding of labelled saxitoxin to the squid giant axon

R D Keynes, J M Ritchie

On the binding of labelled saxitoxin to the squid giant axon

R D Keynes et al. Proc R Soc Lond B Biol Sci. .

Abstract

Measurement of the maximum saturable binding capacity for 3H-labelled saxitoxin in well cleaned giant axons from Loligo forbesi gave a value of 290 +/- 65 (s.e.m.) binding sites per square micrometre of membrane. In samples of the fin nerve the total saturable uptake was 12.4 +/- 2.4 fmol mg-1 wet mass, corresponding to 94 sites per square micrometre for fibres whose mean diameter after fixation and embedding was estimated as 16 micron.

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