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2021
DOI: 10.1021/acsbiomaterials.1c00150
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Poly(aspartic acid) in Biomedical Applications: From Polymerization, Modification, Properties, Degradation, and Biocompatibility to Applications

Abstract: Poly(aspartic acid) (PASP) is an anionic polypeptide that is a highly versatile, biocompatible, and biodegradable polymer that fulfils key requirements for use in a wide variety of biomedical applications. The derivatives of PASP can be readily tailored via the amine-reactive precursor, poly(succinimide) (PSI), which opens up a large window of opportunity for the design and development of novel biomaterials. PASP also has a strong affinity with calcium ions, resulting in complexation, which has been exploited … Show more

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Cited by 97 publications

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“…In the spectrum of PASP, absorption peaks centered at 3300, 1647, 1533, 1599, and 1400 cm −1 are the characteristic absorption peak of the stretching vibration of the N─H, symmetrical telescopic vibration, and bending vibration of ─CONH, and the carboxylate symmetric stretching vibration, respectively. [ 29,31,41,42 ] The appearance of the typical absorption bonds of ─HC═CH 2 centered around 1297 and 947 cm −1 confirms the successful synthesis of PSAP‐AMA. [ 43 ]…”
Section: Results
mentioning
confidence: 70%