Fenacetin

Fenacetin
Klinički podaci
Prodajno ime	Achrocidin, Codempiral, Commotional, Contradol
Drugs.com	Monografija
Identifikatori
CAS broj	62-44-2
ATC kod	N02BE03 (WHO)
PubChem	CID 4754
DrugBank	DB03783
ChemSpider	4590
KEGG	C07591
ChEBI	CHEBI:8050
ChEMBL	CHEMBL16073

Fenacetin je organsko jedinjenje, koje sadrži 10 atoma ugljenika i ima molekulsku masu od 179,216 Da.^[1]^[2]^[3]^[4]^[5]^[6]

Osobine

Osobina	Vrednost
Broj akceptora vodonika	2
Broj donora vodonika	1
Broj rotacionih veza	3
Particioni koeficijent^[7] (ALogP)	1,3
Rastvorljivost^[8] (logS, log(mol/L))	-2,3
Polarna površina^[9] (PSA, Å²)	38,3

Reference

^ Dubach UC, Rosner B, Sturmer T: An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987) N Engl J Med. Dubach, U. C.; Rosner, B.; Stürmer, T. (јануар 1991). . „An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987)”. The New England Journal of Medicine. 324 (3): 155—60. PMID 1984193. doi:10.1056/NEJM199101173240304.
^ Cochran AJ, Lawson DH, Linton AL: Renal papillary necrosis following phenacetin excess. Scott Med J. Cochran, A. J.; Lawson, D. H.; Linton, A. L. (јул 1967). . „Renal papillary necrosis following phenacetin excess”. Scottish Medical Journal. 12 (7): 246—50. PMID 6036245. doi:10.1177/003693306701200702.
^ TAN GH, RABBINO MD, HOPPER J Jr: IS PHENACETIN A NEPHROTOXIN?A REPORT ON TWENTY-THREE USERS OF THE DRUG. Calif Med. ;101:73-7. TAN GH; RABBINO MD; HOPPER J Jr (1964 Aug). . „Is Phenacetin a Nephrotoxin?A Report on Twenty-Three Users of the Drug”. California Medicine. 101 (2): 73—77. PMC 1515485 . PMID 14180501. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Brix AE: Renal papillary necrosis. Toxicol Pathol. ;Brix, A. E. (2002 Nov-Dec). . „Renal papillary necrosis”. Toxicologic Pathology. 30 (6): 672—4. PMID 12512867. doi:10.1080/01926230290166760. Проверите вредност парамет(а)ра за датум: |date= (помоћ)
^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
^ Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
^ Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). . „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
^ Ertl, P.; Rohde, B.; Selzer, P. (2000). . „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

Literatura

Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.

Spoljašnje veze

Phenacetin

Molimo Vas, obratite pažnju na važno upozorenje
u vezi sa temama iz oblasti medicine (zdravlja).

[1] Dubach UC, Rosner B, Sturmer T: An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987) N Engl J Med. Dubach, U. C.; Rosner, B.; Stürmer, T. (јануар 1991). . „An epidemiologic study of abuse of analgesic drugs. Effects of phenacetin and salicylate on mortality and cardiovascular morbidity (1968 to 1987)”. The New England Journal of Medicine. 324 (3): 155—60. PMID 1984193. doi:10.1056/NEJM199101173240304.

[2] Cochran AJ, Lawson DH, Linton AL: Renal papillary necrosis following phenacetin excess. Scott Med J. Cochran, A. J.; Lawson, D. H.; Linton, A. L. (јул 1967). . „Renal papillary necrosis following phenacetin excess”. Scottish Medical Journal. 12 (7): 246—50. PMID 6036245. doi:10.1177/003693306701200702.

[3] TAN GH, RABBINO MD, HOPPER J Jr: IS PHENACETIN A NEPHROTOXIN?A REPORT ON TWENTY-THREE USERS OF THE DRUG. Calif Med. ;101:73-7. TAN GH; RABBINO MD; HOPPER J Jr (1964 Aug). . „Is Phenacetin a Nephrotoxin?A Report on Twenty-Three Users of the Drug”. California Medicine. 101 (2): 73—77. PMC 1515485 . PMID 14180501. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[4] Brix AE: Renal papillary necrosis. Toxicol Pathol. ;Brix, A. E. (2002 Nov-Dec). . „Renal papillary necrosis”. Toxicologic Pathology. 30 (6): 672—4. PMID 12512867. doi:10.1080/01926230290166760. Проверите вредност парамет(а)ра за датум: |date= (помоћ)

[5] Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—41. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.

[6] Wishart, D. S.; Knox, C.; Guo, A. C.; Cheng, D.; Shrivastava, S.; Tzur, D.; Gautam, B.; Hassanali, M. (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—6. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.

[7] Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.

[8] Tetko, I. V.; Tanchuk, V. Y.; Kasheva, T. N.; Villa, A. E. (2001). . „Estimation of aqueous solubility of chemical compounds using E-state indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.

[9] Ertl, P.; Rohde, B.; Selzer, P. (2000). . „Fast calculation of molecular polar surface area as a sum of fragment-based contributions and its application to the prediction of drug transport properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.

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