{"id":"https://openalex.org/W4405754839","doi":"https://doi.org/10.1109/sc41406.2024.00012","title":"Toward Capturing Genetic Epistasis from Multivariate Genome-Wide Association Studies Using Mixed-Precision Kernel Ridge Regression","display_name":"Toward Capturing Genetic Epistasis from Multivariate Genome-Wide Association Studies Using Mixed-Precision Kernel Ridge Regression","publication_year":2024,"publication_date":"2024-11-17","ids":{"openalex":"https://openalex.org/W4405754839","doi":"https://doi.org/10.1109/sc41406.2024.00012"},"language":"en","primary_location":{"id":"doi:10.1109/sc41406.2024.00012","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sc41406.2024.00012","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SC24: International Conference for High Performance Computing, Networking, Storage and Analysis","raw_type":"proceedings-article"},"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091611799","display_name":"Hatem Ltaief","orcid":null},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Hatem Ltaief","raw_affiliation_strings":["King Abdullah University of Science and Technology,Computer, Electrical and Mathematical Sciences and Engineering Division,KSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdullah University of Science and Technology,Computer, Electrical and Mathematical Sciences and Engineering Division,KSA","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013947843","display_name":"Rabab Alomairy","orcid":"https://orcid.org/0000-0001-9911-6094"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Rabab Alomairy","raw_affiliation_strings":["King Abdullah University of Science and Technology,Computer, Electrical and Mathematical Sciences and Engineering Division,KSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdullah University of Science and Technology,Computer, Electrical and Mathematical Sciences and Engineering Division,KSA","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031048186","display_name":"Qinglei Cao","orcid":"https://orcid.org/0000-0002-6690-194X"},"institutions":[{"id":"https://openalex.org/I47838141","display_name":"Saint Louis University","ror":"https://ror.org/01p7jjy08","country_code":"US","type":"education","lineage":["https://openalex.org/I47838141"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qinglei Cao","raw_affiliation_strings":["Saint Louis University,Department of Computer Science,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Saint Louis University,Department of Computer Science,USA","institution_ids":["https://openalex.org/I47838141"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023610301","display_name":"Jie Ren","orcid":"https://orcid.org/0000-0003-3183-7228"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Jie Ren","raw_affiliation_strings":["King Abdullah University of Science and Technology,Computer, Electrical and Mathematical Sciences and Engineering Division,KSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdullah University of Science and Technology,Computer, Electrical and Mathematical Sciences and Engineering Division,KSA","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056066550","display_name":"Lotfi Slim","orcid":"https://orcid.org/0000-0002-5362-7750"},"institutions":[{"id":"https://openalex.org/I4210127875","display_name":"Nvidia (United States)","ror":"https://ror.org/03jdj4y14","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127875"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lotfi Slim","raw_affiliation_strings":["NVIDIA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NVIDIA,USA","institution_ids":["https://openalex.org/I4210127875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051695509","display_name":"Thorsten Kurth","orcid":"https://orcid.org/0000-0003-0832-6198"},"institutions":[{"id":"https://openalex.org/I4210127875","display_name":"Nvidia (United States)","ror":"https://ror.org/03jdj4y14","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127875"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thorsten Kurth","raw_affiliation_strings":["NVIDIA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NVIDIA,USA","institution_ids":["https://openalex.org/I4210127875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107589410","display_name":"Benedikt Dorschner","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127875","display_name":"Nvidia (United States)","ror":"https://ror.org/03jdj4y14","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127875"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Benedikt Dorschner","raw_affiliation_strings":["NVIDIA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NVIDIA,USA","institution_ids":["https://openalex.org/I4210127875"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002870745","display_name":"Salim Bougouffa","orcid":"https://orcid.org/0000-0001-9218-6452"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Salim Bougouffa","raw_affiliation_strings":["King Abdullah University of Science and Technology,Computer, Electrical and Mathematical Sciences and Engineering Division,KSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdullah University of Science and Technology,Computer, Electrical and Mathematical Sciences and Engineering Division,KSA","institution_ids":["https://openalex.org/I71920554"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016451233","display_name":"Rached Abdelkhalak","orcid":null},"institutions":[{"id":"https://openalex.org/I4210127875","display_name":"Nvidia (United States)","ror":"https://ror.org/03jdj4y14","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127875"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rached Abdelkhalak","raw_affiliation_strings":["NVIDIA,USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"NVIDIA,USA","institution_ids":["https://openalex.org/I4210127875"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021283893","display_name":"David E. Keyes","orcid":"https://orcid.org/0000-0002-4052-7224"},"institutions":[{"id":"https://openalex.org/I71920554","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38","country_code":"SA","type":"education","lineage":["https://openalex.org/I71920554"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"David E. Keyes","raw_affiliation_strings":["King Abdullah University of Science and Technology,Computer, Electrical and Mathematical Sciences and Engineering Division,KSA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"King Abdullah University of Science and Technology,Computer, Electrical and Mathematical Sciences and Engineering Division,KSA","institution_ids":["https://openalex.org/I71920554"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"1","last_page":"12"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9498000144958496,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9498000144958496,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.9320999979972839,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9254999756813049,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multivariate-statistics","display_name":"Multivariate statistics","score":0.7699812650680542},{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.6485124230384827},{"id":"https://openalex.org/keywords/ridge","display_name":"Ridge","score":0.5888616442680359},{"id":"https://openalex.org/keywords/kernel","display_name":"Kernel (algebra)","score":0.5628214478492737},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5532149076461792},{"id":"https://openalex.org/keywords/regression","display_name":"Regression","score":0.5344409346580505},{"id":"https://openalex.org/keywords/kernel-regression","display_name":"Kernel regression","score":0.5092400312423706},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.48229292035102844},{"id":"https://openalex.org/keywords/kernel-method","display_name":"Kernel method","score":0.4730730950832367},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.47251567244529724},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.4304545521736145},{"id":"https://openalex.org/keywords/association","display_name":"Association (psychology)","score":0.41900891065597534},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.3653500974178314},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.3350884020328522},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.2572696805000305},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2184845209121704},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.18464213609695435},{"id":"https://openalex.org/keywords/support-vector-machine","display_name":"Support vector machine","score":0.17252770066261292},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.1512015163898468},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.11119791865348816},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.08569580316543579}],"concepts":[{"id":"https://openalex.org/C161584116","wikidata":"https://www.wikidata.org/wiki/Q1952580","display_name":"Multivariate statistics","level":2,"score":0.7699812650680542},{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.6485124230384827},{"id":"https://openalex.org/C32277403","wikidata":"https://www.wikidata.org/wiki/Q740445","display_name":"Ridge","level":2,"score":0.5888616442680359},{"id":"https://openalex.org/C74193536","wikidata":"https://www.wikidata.org/wiki/Q574844","display_name":"Kernel (algebra)","level":2,"score":0.5628214478492737},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5532149076461792},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.5344409346580505},{"id":"https://openalex.org/C200695384","wikidata":"https://www.wikidata.org/wiki/Q1739319","display_name":"Kernel regression","level":3,"score":0.5092400312423706},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.48229292035102844},{"id":"https://openalex.org/C122280245","wikidata":"https://www.wikidata.org/wiki/Q620622","display_name":"Kernel method","level":3,"score":0.4730730950832367},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.47251567244529724},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.4304545521736145},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.41900891065597534},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.3653500974178314},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3350884020328522},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.2572696805000305},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2184845209121704},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.18464213609695435},{"id":"https://openalex.org/C12267149","wikidata":"https://www.wikidata.org/wiki/Q282453","display_name":"Support vector machine","level":2,"score":0.17252770066261292},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.1512015163898468},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.11119791865348816},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.08569580316543579},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C542102704","wikidata":"https://www.wikidata.org/wiki/Q183257","display_name":"Psychotherapist","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1109/sc41406.2024.00012","is_oa":false,"landing_page_url":"https://doi.org/10.1109/sc41406.2024.00012","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SC24: International Conference for High Performance Computing, Networking, Storage and Analysis","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.47999998927116394}],"awards":[],"funders":[{"id":"https://openalex.org/F4320322320","display_name":"King Abdullah University of Science and Technology","ror":"https://ror.org/01q3tbs38"},{"id":"https://openalex.org/F4320338287","display_name":"Oak Ridge National Laboratory","ror":"https://ror.org/01qz5mb56"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W1966775465","https://openalex.org/W1975721804","https://openalex.org/W1975818677","https://openalex.org/W1988201922","https://openalex.org/W2061187129","https://openalex.org/W2087440962","https://openalex.org/W2089073798","https://openalex.org/W2094189284","https://openalex.org/W2113784410","https://openalex.org/W2121893797","https://openalex.org/W2135046866","https://openalex.org/W2163953557","https://openalex.org/W2168029744","https://openalex.org/W2171250718","https://openalex.org/W2744399788","https://openalex.org/W2752879223","https://openalex.org/W2787894218","https://openalex.org/W2895305554","https://openalex.org/W2895486342","https://openalex.org/W2991212521","https://openalex.org/W2998672756","https://openalex.org/W3036789636","https://openalex.org/W3042983441","https://openalex.org/W3162800482","https://openalex.org/W3165254043","https://openalex.org/W3195285310","https://openalex.org/W3203277023","https://openalex.org/W4221069327","https://openalex.org/W4239514724","https://openalex.org/W4281657881","https://openalex.org/W4313130501","https://openalex.org/W4313299691","https://openalex.org/W4317390883","https://openalex.org/W4321636543","https://openalex.org/W4367147548","https://openalex.org/W4376456357","https://openalex.org/W4388855622","https://openalex.org/W6927419316"],"related_works":["https://openalex.org/W2140249224","https://openalex.org/W2594299395","https://openalex.org/W2066467839","https://openalex.org/W2111842731","https://openalex.org/W2170506381","https://openalex.org/W2765794416","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W1486217206","https://openalex.org/W1992310781"],"abstract_inverted_index":{"We":[0,92,112],"exploit":[1],"the":[2,16,32,35,65,87,99,116,139],"widening":[3],"margin":[4],"in":[5],"tensor-core":[6],"performance":[7,17],"between":[8],"[FP64/FP32/FP16/INT8,FP64/FP32/FP16/FP8/INT8]":[9],"on":[10,132],"NVIDIA":[11],"[Ampere,Hopper]":[12],"GPUs":[13],"to":[14,83,104],"boost":[15],"of":[18,23,28,67,86,115,148],"output":[19],"accuracy-preserving":[20],"mixed-precision":[21,130],"computation":[22,100],"Genome-Wide":[24],"Association":[25],"Studies":[26],"(GWAS)":[27],"305K":[29],"patients":[30],"from":[31],"UK":[33],"BioBank,":[34],"largest-ever":[36],"GWAS":[37,74,143],"cohort":[38],"studied":[39],"for":[40,73,101],"genetic":[41],"epistasis":[42],"using":[43],"a":[44,122,133],"multivariate":[45],"approach.":[46],"Tile-centric":[47],"adaptive-precision":[48],"linear":[49],"algebraic":[50],"techniques":[51,72],"motivated":[52],"by":[53,97,120,145],"reducing":[54],"data":[55],"motion":[56],"gain":[57],"enhanced":[58],"significance":[59],"with":[60],"low-precision":[61],"GPU":[62],"arithmetic.":[63],"At":[64],"core":[66],"Kernel":[68],"Ridge":[69],"Regression":[70],"(KRR)":[71],"lie":[75],"compute-bound":[76],"cubic-complexity":[77],"matrix":[78,95],"operations":[79],"that":[80],"inhibit":[81],"scaling":[82],"aspirational":[84],"dimensions":[85],"population,":[88],"genotypes,":[89],"and":[90],"phenotypes.":[91],"accelerate":[93,113],"KRR":[94,118],"generation":[96],"redesigning":[98],"Euclidean":[102],"distances":[103],"engage":[105],"INT8":[106],"tensor":[107],"cores":[108],"while":[109],"exploiting":[110],"symmetry.":[111],"solution":[114],"regularized":[117],"systems":[119],"deploying":[121],"new":[123],"four-precision":[124],"Cholesky-based":[125],"solver,":[126],"which,":[127],"at":[128],"1.805":[129],"ExaOp/s":[131],"nearly":[134],"full":[135],"Alps":[136],"system,":[137],"outperforms":[138],"state-of-the-art":[140],"CPU-only":[141],"REGENIE":[142],"software":[144],"five":[146],"orders":[147],"magnitude.":[149]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":10}],"updated_date":"2026-07-17T09:13:05.818461","created_date":"2025-10-10T00:00:00"}