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Case Reports
. 2004 Mar 6;328(7439):572-4.
doi: 10.1136/bmj.328.7439.572.

Severe cholestatic hepatitis induced by pyritinol

Vasco Maria  1 , Adriana Albuquerque, Ana Loureiro, Ana Sousa, Rui Victorino
Affiliations
Case Reports

Severe cholestatic hepatitis induced by pyritinol

Vasco Maria et al. BMJ. .
No abstract available

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Figures

Fig 1
Fig 1
Lymphocyte proliferative responses to pyritinol. Drug stimulation indices in five patients and nine controls assessed by 3H thymidine incorporation after a pulse of 1 microcurie in the previous six hours of the culture and counted in a gaseous scintillation β counter. Values ≤2 are considered to be normal
Fig 2
Fig 2
Characterisation of the T cell subsets contributing to the proliferative response in a patient and in a healthy control. Cells were intracellularly stained with antibromodeoxyuridine (BrdU) monoclonal antibody after incubation with BrdU during the previous 24 hours of the culture. Numbers in the upper right quadrant represent the percentage of T cells that are CD4+ and BrdU+, and those in the lower right quadrant represent the percentage of T cells that are CD4- (CD8+) and BrdU+
See this image and copyright information in PMC

References

    1. Lemmel EM. Comparison of pyritinol and auranofin in the treatment of rheumatoid arthritis. Br J Rheumatol 1993;32: 375-82. - PubMed
    1. Jaffe IA. Adverse effects profile of sulfhydryl compounds in man. Am J Med 1986;80: 471-6. - PubMed
    1. Maria VA, Victorino RM. Diagnostic value of specific T cell reactivity to drugs in 95 cases of drug induced liver injury. Gut 1997;41: 534-40. - PMC - PubMed
    1. Cavaleiro R, Sousa AE, Loureiro A, Victorino RM. Marked immunosuppressive effects of HIV-2 envelope protein in spite of the lower HIV-2 pathogenicity. AIDS 2000;14: 2679-86. - PubMed
    1. Macedo G, Sarmento JA, Allegro S. Acute hepatitis due to pyritinol. Gastroenterol Clin Biol 1992;16: 186-7. - PubMed

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