Effectiveness of typhoid vaccination in US travelers

“…Three currently available typhoid vaccines are recommended by the WHO: an oral vaccine based on a live attenuated mutant strain of STY Ty21a (Ty21a), the injectable Vi capsular polysaccharide (ViCPS) vaccine and the typhoid conjugate vaccine (TCV) (http://www.who.int/immunization/policy/position_papers/typhoid/en/). However, these Typhi vaccines do not provide protection against paratyphoid fever caused by SPTA [44], and hence, a vaccine that protects against typhoid and paratyphoid fever would be of high value. When selecting antigens for developing new diagnostics or vaccines for both STY and SPTA, one should take into account that although encoded in both serovars, membrane proteins can be differentially expressed between both serovars and this should be tested in vitro and in vivo.…”

Section: Discussion

mentioning

confidence: 99%

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Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes reveal differentially expressed proteins linked to the cell surface and pathogenicity

Saleh

¹

,

Puyvelde

²

,

Staes

³

et al. 2019

PLoS Negl Trop Dis

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Three currently available typhoid vaccines are recommended by the WHO: an oral vaccine based on a live attenuated mutant strain of STY Ty21a (Ty21a), the injectable Vi capsular polysaccharide (ViCPS) vaccine and the typhoid conjugate vaccine (TCV) (http://www.who.int/immunization/policy/position_papers/typhoid/en/). However, these Typhi vaccines do not provide protection against paratyphoid fever caused by SPTA [44], and hence, a vaccine that protects against typhoid and paratyphoid fever would be of high value. When selecting antigens for developing new diagnostics or vaccines for both STY and SPTA, one should take into account that although encoded in both serovars, membrane proteins can be differentially expressed between both serovars and this should be tested in vitro and in vivo.…”

Section: Discussion

mentioning

confidence: 99%

Get access via publisher

Enteric fever among children: 50 cases in a French tertiary care centre

Pommelet

¹

,

Mariani

²

,

Basmaci

³

et al. 2018

Journal of Travel Medicine

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…25 The effectiveness of both vaccines is moderate and ranges from 60% to 80% and appears to be similar among travellers as among population in endemic regions. [26][27][28] Conflicting results have been published in children from 2 to 5 years old, effectiveness varying from 35% in Pakistan to 80% in India but was similar to adults in travellers from UK. 28 Furthermore, these vaccines are effective only against S.…”

Section: Discussion

mentioning

confidence: 99%

Get access via publisher

Changing Patterns in Enteric Fever Incidence and Increasing Antibiotic Resistance of Enteric Fever Isolates in the United States, 2008–2012

Date

¹

,

Newton

²

,

Medalla

³

et al. 2016

Clin Infect Dis.

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Though effective, available typhoid vaccines have limitations. The protection is moderate—about 80% for US travelers [46]. Typhoid vaccines provide no protection against Paratyphi A infections, cannot be given to children <2 years old, and provide protection for only 2–5 years.…”

Section: Discussion

mentioning

confidence: 99%

Get access via publisher

Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes reveal differentially expressed proteins linked to the cell surface and pathogenicity

Saleh

¹

,

Puyvelde

²

,

Staes

³

et al. 2019

PLoS Negl Trop Dis

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Three currently available typhoid vaccines are recommended by the WHO: an oral vaccine based on a live attenuated mutant strain of STY Ty21a (Ty21a), the injectable Vi capsular polysaccharide (ViCPS) vaccine and the typhoid conjugate vaccine (TCV) (http://www.who.int/immunization/policy/position_papers/typhoid/en/). However, these Typhi vaccines do not provide protection against paratyphoid fever caused by SPTA [44], and hence, a vaccine that protects against typhoid and paratyphoid fever would be of high value. When selecting antigens for developing new diagnostics or vaccines for both STY and SPTA, one should take into account that although encoded in both serovars, membrane proteins can be differentially expressed between both serovars and this should be tested in vitro and in vivo.…”

Section: Discussion

mentioning

confidence: 99%

Get access via publisher

Enteric fever among children: 50 cases in a French tertiary care centre

Pommelet

¹

,

Mariani

²

,

Basmaci

³

et al. 2018

Journal of Travel Medicine

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…25 The effectiveness of both vaccines is moderate and ranges from 60% to 80% and appears to be similar among travellers as among population in endemic regions. [26][27][28] Conflicting results have been published in children from 2 to 5 years old, effectiveness varying from 35% in Pakistan to 80% in India but was similar to adults in travellers from UK. 28 Furthermore, these vaccines are effective only against S.…”

Section: Discussion

mentioning

confidence: 99%

Get access via publisher

Changing Patterns in Enteric Fever Incidence and Increasing Antibiotic Resistance of Enteric Fever Isolates in the United States, 2008–2012

Date

¹

,

Newton

²

,

Medalla

³

et al. 2016

Clin Infect Dis.

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Though effective, available typhoid vaccines have limitations. The protection is moderate—about 80% for US travelers [46]. Typhoid vaccines provide no protection against Paratyphi A infections, cannot be given to children <2 years old, and provide protection for only 2–5 years.…”

Section: Discussion

mentioning

confidence: 99%

Get access via publisher

Salmonella Typhi, Paratyphi A, Enteritidis and Typhimurium core proteomes reveal differentially expressed proteins linked to the cell surface and pathogenicity

Saleh

¹

,

Puyvelde

²

,

Staes

³

et al. 2019

PLoS Negl Trop Dis

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Three currently available typhoid vaccines are recommended by the WHO: an oral vaccine based on a live attenuated mutant strain of STY Ty21a (Ty21a), the injectable Vi capsular polysaccharide (ViCPS) vaccine and the typhoid conjugate vaccine (TCV) (http://www.who.int/immunization/policy/position_papers/typhoid/en/). However, these Typhi vaccines do not provide protection against paratyphoid fever caused by SPTA [44], and hence, a vaccine that protects against typhoid and paratyphoid fever would be of high value. When selecting antigens for developing new diagnostics or vaccines for both STY and SPTA, one should take into account that although encoded in both serovars, membrane proteins can be differentially expressed between both serovars and this should be tested in vitro and in vivo.…”

Section: Discussion

mentioning

confidence: 99%

Get access via publisher

Enteric fever among children: 50 cases in a French tertiary care centre

Pommelet

¹

,

Mariani

²

,

Basmaci

³

et al. 2018

Journal of Travel Medicine

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…25 The effectiveness of both vaccines is moderate and ranges from 60% to 80% and appears to be similar among travellers as among population in endemic regions. [26][27][28] Conflicting results have been published in children from 2 to 5 years old, effectiveness varying from 35% in Pakistan to 80% in India but was similar to adults in travellers from UK. 28 Furthermore, these vaccines are effective only against S.…”

Section: Discussion

mentioning

confidence: 99%

Get access via publisher

Changing Patterns in Enteric Fever Incidence and Increasing Antibiotic Resistance of Enteric Fever Isolates in the United States, 2008–2012

Date

¹

,

Newton

²

,

Medalla

³

et al. 2016

Clin Infect Dis.

Self Cite

Abstract

Smart CitationsHow this paper cites the one you are viewing

“…Though effective, available typhoid vaccines have limitations. The protection is moderate—about 80% for US travelers [46]. Typhoid vaccines provide no protection against Paratyphi A infections, cannot be given to children <2 years old, and provide protection for only 2–5 years.…”

Section: Discussion

mentioning

confidence: 99%

Get access via publisher