Soy isoflavone consumption and colorectal cancer risk: a systematic review and meta-analysis

Yu, Yi; Jing, Xiaoli; Li, Hui; Zhao, Xiang; Wang, Dongping

doi:10.1038/srep25939

Sci Rep

2016

DOI: 10.1038/srep25939

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Soy isoflavone consumption and colorectal cancer risk: a systematic review and meta-analysis

Yi Yu

¹

,

Xiaoli Jing

²

,

Hui Li

³

et al.

Abstract: Colorectal cancer (CRC) is one of the most predominant solid carcinomas in Western countries. However, there is conflicting information on the effects of soy isoflavone on CRC risk. Therefore, we performed a meta-analysis to assess the association between soy isoflavone consumption and CRC risk in humans using PubMed, Embase, Web of Science, and Cochrane Library databases. A total of 17 epidemiologic studies, which consisted of thirteen case-control and four prospective cohort studies, met the inclusion criter… Show more

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Cited by 69 publications

(48 citation statements)

References 46 publications

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1

Mentioning

45

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“…Poor diet is a major contributor to CRC risk and has become a growing concern [ 92 ]. Our results are in line with those of other studies, which indicated that a high intake of meat was associated with a higher risk of CRC [ 93 - 95 ], while a high intake of fruits and vegetables [ 96 , 97 ], fibre [ 98 , 99 ], and legumes [ 100 , 101 ] was associated with a lower risk. Vitamins are known to have a strong antioxidant effect and can reduce free radical damage to the body [ 102 ].…”

Section: Discussionsupporting

confidence: 92%

National and subnational incidence, mortality and associated factors of colorectal cancer in China: A systematic analysis and modelling study

Xu

¹

,

Zhao

²

,

Li

³

et al. 2023

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…Poor diet is a major contributor to CRC risk and has become a growing concern [ 92 ]. Our results are in line with those of other studies, which indicated that a high intake of meat was associated with a higher risk of CRC [ 93 - 95 ], while a high intake of fruits and vegetables [ 96 , 97 ], fibre [ 98 , 99 ], and legumes [ 100 , 101 ] was associated with a lower risk. Vitamins are known to have a strong antioxidant effect and can reduce free radical damage to the body [ 102 ].…”

Section: Discussionsupporting

confidence: 92%

National and subnational incidence, mortality and associated factors of colorectal cancer in China: A systematic analysis and modelling study

Xu

¹

,

Zhao

²

,

Li

³

et al. 2023

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“…We know from the previous studies that isoflavone-rich soy products may increase estradiol in postmenopausal women, 17 and higher isoflavone intake is associated with lower risk of CRC. 16 Assuming that our population with high SHBG levels had lower circulating levels of free estradiol and estrone, those with high isoflavone intake may have had a lower risk of developing CRC possibly by increasing estradiol levels despite high SHBG levels. In contrast, those with low isoflavone intake had a greater risk of developing CRC due to lower estradiol levels as a result.…”

Section: Discussionmentioning

confidence: 85%

“…We observed a significant positive association between SHBG levels and CRC risk among those with low isoflavone intake, while those with high isoflavone intake have a lower risk of CRC. We know from the previous studies that isoflavone‐rich soy products may increase estradiol in postmenopausal women, and higher isoflavone intake is associated with lower risk of CRC . Assuming that our population with high SHBG levels had lower circulating levels of free estradiol and estrone, those with high isoflavone intake may have had a lower risk of developing CRC possibly by increasing estradiol levels despite high SHBG levels.…”

Section: Discussionmentioning

confidence: 87%

Circulating sex hormone levels and colorectal cancer risk in Japanese postmenopausal women: The JPHC nested case–control study

Mori¹,

Sawada²,

Iwasaki³

et al. 2019

Intl Journal of Cancer

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Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

“… 15 , Yu et al . 26 and Zhu et al . 49 reported that soy consumption had an inverse association with CRC.…”

Section: Discussionmentioning

confidence: 93%

Meta-analysis of Soy Consumption and Gastrointestinal Cancer Risk

Lu

¹

,

Ye

²

,

Duan

³

et al. 2017

Sci Rep

Get access via publisher Add to collection Cite

Exaggerated anticipatory anxiety is common in social anxiety disorder (SAD). Neuroimaging studies have revealed altered neural activity in response to social stimuli in SAD, but fewer studies have examined neural activity during anticipation of feared social stimuli in SAD. The current study examined the time course and magnitude of activity in threat processing brain regions during speech anticipation in socially anxious individuals and healthy controls (HC). Method Participants (SAD n = 58; HC n = 16) underwent functional magnetic resonance imaging (fMRI) during which they completed a 90s control anticipation task and 90s speech anticipation task.

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