Hidroksizin

Hidroksizin
(IUPAC) ime
	(±)-2-(24-[(4-hlorofenil)-fenilmetil]piperazin-1-il
Klinički podaci
Identifikatori
ATC kod	?
Hemijski podaci
Formula	?
Farmakoinformacioni podaci
Trudnoća	?
Pravni status

etoksi)etanol

| image = Hydroxyzine.svg | width = | image2 = Hydroxyzine-3d-sticks.png | width2 =

| DrugBank = DB00557

| C = 21 | H = 27 | Cl = 1 | N = 2 | O = 2

| molecular_weight = 374,904 g/mol | smiles = Clc1ccc(cc1)C(c2ccccc2)N3CCN(CC3)CCOCCO | InChI = 1/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2 | InChIKey = ZQDWXGKKHFNSQK-UHFFFAOYAL | StdInChI_Ref = ^Y | StdInChI = 1S/C21H27ClN2O2/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25/h1-9,21,25H,10-17H2 | StdInChIKey_Ref = ^Y | StdInChIKey = ZQDWXGKKHFNSQK-UHFFFAOYSA-N }}

Hidroksizin (Vistaril, Ataraks) pripada prvoj generaciji antihistamina difenilmetanske i piperazinske klase. On je prvi put sintetisan 1956. i u prodaji je bio od strane kompanije Pfizer u SAD-u iste godine.^[2] On je još uvek u širokoj upotrebi.

Hemija

Hidroksizin se može sintetisati alkilacijom 1-(4-hlorobenzohidril)piperazina sa 2-(2-hidroksietoksi)etilhloridom:^[3]

Reference

↑ Simons FE, Simons KJ, Frith EM (January 1984). „The pharmacokinetics and antihistaminic of the H1 receptor antagonist hydroxyzine”. The Journal of Allergy and Clinical Immunology 73 (1 Pt 1): 69–75. PMID 6141198.
↑ Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-536874-6.
↑ H. Morren, U.S. Patent 2.899.436 (1959); H. Morren, DE 1049383 (1954); H. Morren, DE 1061786 (1954); H. Morren, DE 1068262 (1954); H. Morren, DE 1072624 (1954); H. Morren, DE 1075116 (1954).

Literatura

Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-536874-6.

Hutcheon, D. E.; D.L. Morris, A. Scriabine (December 1956). „Cardiovascular action of hydroxyzine (Atarax)”. J Pharmacol Exp Ther. 118 (4): 451–460. PMID 13385806.
Dolan, C. M. (June 1958). „MANAGEMENT OF EMOTIONAL DISTURBANCES—Use of Hydroxyzine (Atarax®) in General Practice”. Calif Med. 88 (6): 443–444. PMC 1512309. PMID 13536863.
Pfizer Labs, Division of Pfizer Inc, NY, NY 10017 (2004) (pdf). Vistaril (hydroxyzine pamoate) Capsules and Oral Suspension. United States Food and Drug Administration.
Anderson, Philip O.; James E. Knoben, William G. Troutman (2002). Handbook of Clinical Drug Data. McGraw-Hill Medical. ISBN 0-07-136362-9.
de Brabander, A.; W. Deberdt (1990). „Effect of Hydroxyzine on Attention and Memory”. Human Psychopharmacology (John Wiley & Sons) 5 (4): 357–362. DOI:10.1002/hup.470050408. Pristupljeno 2007-03-09. ^{[mrtav link]}
Clark, B. G.; M. Araki, H. W. Brown (1982). „Hydroxyzine-Associated Tardive Dyskinesia”. Ann Neurol. 11 (4): 435. DOI:10.1002/ana.410110423. PMID 7103423.
Porsolt, R. D.; P. Martin, A. Lenegre, S. Frornage, and C.E. Giurgea (1989). „Prevention of "Learned Helplessness" in the Rat by Hydroxyzine”. Drug Dev. Res. 17 (3): 227–236. DOI:10.1002/ddr.430170306. Pristupljeno 2007-03-10. ^{[mrtav link]}
Alford, C.; N. Rombautt, J. Jones, S. Foley, C. Idzikowskit and I. Hindmarch (1992). „Acute Effects of Hydroxyzine on Nocturnal Sleep and Sleep Tendency the Following Day: a C-EEG Study”. Human Psychopharmacology 7 (1): 25–35. DOI:10.1002/hup.470070104. Pristupljeno 2007-03-10. ^{[mrtav link]}
RxList, et al. (2004). „Atarax Indications, Dosage, Storage, Stability”. RxList - The internet drug index. Arhivirano iz originala na datum 2008-09-06. Pristupljeno 9. 3. 2007.
Medscape (2004). „Vistaril Oral: Monograph - Hydroxyzine Hydrochloride, Hydroxyzine Pamoate”. medscape.com. Pristupljeno 9. 3. 2007.

Vanjske veze

	Portal Medicina
	Portal Hemija

U.S. National Library of Medicine: Drug Information Portal - Hydroxyzine

Šablon:Sedativi

[pmid6141198-1] Simons FE, Simons KJ, Frith EM (January 1984). „The pharmacokinetics and antihistaminic of the H1 receptor antagonist hydroxyzine”. The Journal of Allergy and Clinical Immunology 73 (1 Pt 1): 69–75. PMID 6141198.

[isbn0-19-536874-6-2] Shorter, Edward (2009). Before Prozac: the troubled history of mood disorders in psychiatry. Oxford [Oxfordshire]: Oxford University Press. ISBN 0-19-536874-6.

[3] H. Morren, U.S. Patent 2.899.436 (1959); H. Morren, DE 1049383 (1954); H. Morren, DE 1061786 (1954); H. Morren, DE 1068262 (1954); H. Morren, DE 1072624 (1954); H. Morren, DE 1075116 (1954).

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