Abstract
Electronic health records contain valuable information written in narrative form. A relevant challenge in clinical narrative text is that concepts commonly appear negated. Several proposals have been developed to detect negation in clinical text written in Spanish. Much of these proposals have adapted the Negex algorithm to Spanish, but obtained results indicating lower performance than NegEx implementations in other languages. Moreover, in most of these proposals, the validation process could be improved using a shared test corpus focused on negation in clinical text. This paper proposes Spa-neg, an approach to improve negation detection in clinical text written in Spanish. Spa-neg combines three elements: (i) an exploratory data analysis of how negation is written in the clinical text, (ii) use of regular expressions best adapted to the way in which negation is expressed in Spanish, (iii) experiments, and validation using a shared annotated corpus focused on negation. Our findings suggest that the combination of these elements improves the process of negation detection. The tests performed have shown 92% F-Score using IULA Spanish, an annotated corpus for negation in clinical text.
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References
Aronson, A.R., Lang, F.M.: An overview of MetaMap: historical perspective and recent advances. J. Am. Med. Inform. Assoc. 17(3), 229–236 (2010). https://doi.org/10.1136/jamia.2009.002733
Ballesteros, M., Francisco, V., Díaz, A., Herrera, J., Gervás, P.: Inferring the scope of negation in biomedical documents. In: Gelbukh, A. (ed.) CICLing 2012, Part I. LNCS, vol. 7181, pp. 363–375. Springer, Heidelberg (2012). https://doi.org/10.1007/978-3-642-28604-9_30
Barigou, B.N., Barigou, F., Atmani, B.: Handling negation to improve information retrieval from French clinical reports. J. E-Learning Knowl. Soc. 14(1), 11–31 (2018). https://doi.org/10.20368/1971-8829/1455
Budrionis, A., Dalianis, H., Yigzaw, K.Y., Makhlysheva, A., Chomutare, T.: Negation detection in Norwegian medical text: porting a Swedish NegEx to Norwegian. Work in progress (2018)
Chapman, W.W., Bridewell, W., Hanbury, P., Cooper, G.F., Buchanan, B.G.: A simple algorithm for identifying negated findings and diseases in discharge summaries. J. Biomed. Inform. 34(5), 301–310 (2001). https://doi.org/10.1006/jbin.2001.1029
Chapman, W.W., et al.: Extending the NegEx lexicon for multiple languages. Stud. Health Technol. Inform. 192(1–2), 677–681 (2013). https://doi.org/10.3233/978-1-61499-289-9-677
Costumero, R., Lopez, F., Gonzalo-Martín, C., Millan, M., Menasalvas, E.: An approach to detect negation on medical documents in Spanish. In: Ślȩzak, D., Tan, A.-H., Peters, J.F., Schwabe, L. (eds.) BIH 2014. LNCS (LNAI), pp. 366–375. Springer, Cham (2014). https://doi.org/10.1007/978-3-319-09891-3_34
Cruz Díaz, N.P., Maña López, M.J.: Negation and Speculation Detection. Editorial Assistant (2019). https://doi.org/10.1075/nlp.13
Cruz Díaz, N.P., Maña López, M.J., Vázquez, J.M., Álvarez, V.P.: A machine-learning approach to negation and speculation detection in clinical texts. J. Am. Soc. Inform. Sci. Technol. 63(7), 1398–1410 (2012). https://doi.org/10.1002/asi.22679
De Albornoz, J.C., Plaza, L., Diaz, A., Ballesteros, M.: UCM-I: a rule-based syntactic approach for resolving the scope of negation. In: *SEM 2012–1st Joint Conference on Lexical and Computational Semantics, vol. 1, pp. 282–287 (2012)
Donatelli, L.: Cues, scope, and focus: annotating negation in Spanish corpora. In: CEUR Workshop Proceedings, vol. 2174, pp. 29–34 (2018)
Elazhary, H.: NegMiner: an automated tool for mining negations from electronic narrative medical documents. Int. J. Intell. Syst. Appl. 9(4), 14–22 (2017). https://doi.org/10.5815/ijisa.2017.04.02
GitHub: NegEX-MES: NegEX para textos médicos en ESpanol. https://octoverse.github.com/. (Santamaria, J)
Jiménez-Zafra, S.M., Cruz Díaz, N.P., Morante, R., Martín-Valdivia, M.T.: Neges 2018: workshop on negation in Spanish. Procesamiento de Lenguaje Natural 62, 21–28 (2019). https://doi.org/10.26342/2019-62-2
Koza, W., Filippo, D., Cotik, V., Vanessa, S., Ricardo, M.G.: Automatic detection of negated findings in radiological reports for Spanish language: methodology based on lexicon-grammatical information processing. J. Digit. Imaging 1, 19–29 (2019)
Martí Antonín, M.A., Taulé Delor, M., Nofre, M., Marsó, L., Martín Valdivia, M.T., Jiménez Zafra, S.M.: La negación en español: análisis y tipología de patrones de negación (2016). http://rua.ua.es/dspace/handle/10045/57750
Mehrabi, S., et al.: DEEPEN: a negation detection system for clinical text incorporating dependency relation into NegEx. J. Biomed. Inform. 54, 213–219 (2015). https://doi.org/10.1016/j.jbi.2015.02.010
Morante, R., Blanco, E.: SEM 2012 shared task: resolving the scope and focus of negation. In: SEM 2012–1st Joint Conference on Lexical and Computational Semantics, vol. 1, pp. 265–274 (2012)
Névéol, A., Dalianis, H., Velupillai, S., Savova, G., Zweigenbaum, P.: Clinical Natural Language Processing in languages other than English: opportunities and challenges. J. Biomed. Semant. 9(1), 1–13 (2018). https://doi.org/10.1186/s13326-018-0179-8
Syntactic methods for negation detection in radiology reports in Spanish. In: Proceedings of the 15th Workshop on Biomedical Natural Language Processing, BioNLP 2016, Berlin, Germany, 12 August 2016 (2016). https://doi.org/10.18653/v1/w16-2921
Negation detection in clinical reports written in German. In: Proceedings of the 5th Workshop on Building and Evaluating Resources for Biomedical Text Mining (BioTxtM 2016) (2016). http://www.aclweb.org/anthology/W16-5113
Detecting the scope of negations in clinical notes. In: Proceedings of the Second Italian Conference on Computational Linguistics CLiC-IT 2015 (2016)
Annotating negation in Spanish clinical texts. In: Proceedings of the Workshop Computational Semantics Beyond Events and Roles (2017). https://doi.org/10.18653/v1/w17-1808
Annotation of negation in the IULA Spanish clinical record corpus. In: Proceedings of the Workshop Computational Semantics Beyond Events and Roles, Valencia, Spain (2017). https://doi.org/10.18653/v1/w17-1807
Savova, G.K., et al.: Mayo clinical text analysis and knowledge extraction system (cTAKES): architecture, component evaluation and applications. J. Am. Med. Inform. Assoc. 17(5), 507–513 (2010). https://doi.org/10.1136/jamia.2009.001560
Tanushi, H., Dalianis, H., Duneld, M., Kvist, M., Skeppstedt, M., Velupillai, S.: Negation scope delimitation in clinical text using three approaches: NegEx, PyConTextNLP and SynNeg. In: Proceedings of the 19th Nordic Conference of Computational Linguistics (NODALIDA 2013), vol. 1, no. 1, pp. 387–397 (2013)
TIJCAI 2015: negated findings detection in radiology reports in Spanish: an adaptation of NegEx to Spanish (2015)
Velupillai, S., et al.: Using clinical natural language processing for health outcomes research: overview and actionable suggestions for future advances. J. Biomed. Inform. 88, 11–19 (2018). https://doi.org/10.1016/j.jbi.2018.10.005
Vincze, V., Szarvas, G., Farkas, R., Móra, G., Csirik, J.: The BioScope corpus: biomedical texts annotated for uncertainty, negation and their scopes. BMC Bioinform. 9(11), 38–45 (2008). https://doi.org/10.1186/1471-2105-9-S11-S9
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This paper is supported by European Union’s Horizon 2020 research and innovation program under grant agreement No. 727658, project IASIS (Integration and analysis of heterogeneous big data for precision medicine and suggested treatments for different types of patients).
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Solarte-Pabón, O., Menasalvas, E., Rodriguez-González, A. (2020). Spa-neg: An Approach for Negation Detection in Clinical Text Written in Spanish. In: Rojas, I., Valenzuela, O., Rojas, F., Herrera, L., Ortuño, F. (eds) Bioinformatics and Biomedical Engineering. IWBBIO 2020. Lecture Notes in Computer Science(), vol 12108. Springer, Cham. https://doi.org/10.1007/978-3-030-45385-5_29
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