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  • A systematic evaluation shows that contemporary humanoid robots can perform laparoscopic surgical tasks through teleoperation, highlighting both their promise and key technical challenges before clinical deployment.

    • Zekai Liang
    • Nikita Thareja
    • Michael Yip
    Article
  • Epitope editing of KIT enables antibody-based, non-genotoxic conditioning that selectively enriches therapeutic BCL11A-edited haematopoietic stem/progenitor cells, supports durable engraftment, preserves clonal diversity and enhances induction of fetal haemoglobin, a therapeutic approach for conditions such as sickle cell disease and β-thalassemia.

    • Gabriele Casirati
    • Andrea Cosentino
    • Pietro Genovese
    ArticleOpen Access
  • By integrating reinforcement learning with quantum error correction, a quantum computer continuously self-calibrates during computation, achieving record logical error rates and enhanced resilience to drift.

    • Volodymyr Sivak
    • Alexis Morvan
    • Paul V. Klimov
    ArticleOpen Access
  • Large language models can be used to estimate the results of social science experiments about as accurately as a group of human forecasters—even for experiments published after the models were trained—although they tended to overestimate effect sizes.

    • Ashwini Ashokkumar
    • Luke Hewitt
    • Robb Willer
    Article
  • Pharmacological screening and behavioural assays in ants identify two specific neuropeptides that have key and opposite effects in regulating brood care, and that link nutritional state to age-dependent changes in parenting behaviour.

    • Alexander Paul
    • Tomas Kay
    • Daniel J. C. Kronauer
    ArticleOpen Access
  • By combining hydroacoustic, direct-path ranging and bottom-pressure measurements, in situ observations of a rifting event at a segment of the Southeast Indian Ridge are reported, providing insight into seafloor spreading events on yearly timescales.

    • Jean-Yves Royer
    • Jean-Arthur Olive
    • L. Testut
    ArticleOpen Access
  • This Review examines the opportunities and challenges introduced by new datasets and computational techniques in urban crime research, and outlines future directions for leveraging these advances effectively.

    • Gian Maria Campedelli
    • Zubin Jelveh
    • Patrick Sharkey
    Review Article
  • Radio-frequency switches made from two-dimensional layered hexagonal boron nitride (hBN) were co-integrated on gallium nitride (GaN) microchips to build programmable millimetre-wave (mmWave) monolithic microwave integrated circuits suitable for 6G hardware.

    • Sebastian Pazos
    • Andrés Fontana
    • Mario Lanza
    Article
  • Viscoelastic phase separation is used to fabricate non-collapsible, air-rich networks in high-water-content hydrogels containing silica aerogel beads, allowing air to permeate through the material and enabling a tenfold increase in oxygen permeability over pristine hydrogels.

    • Xiao-Yun Yan
    • Shucong Li
    • Xuanhe Zhao
    ArticleOpen Access
  • By observing the neutrons induced by spallation from protons in the inner Van Allen radiation belts using widely available sensor technologies, the detection of a thermonuclear weapon carried by a space satellite is possible.

    • Areg Danagoulian
    Article
  • Screening of chromosome arm-level aneuploidies uncovers that these alterations select for specific basal-like breast cancer driver genes, including PLGRKT, an oncogene whose tumour-promoting activity is associated with highly stress-resistant mitochondria and enhanced detoxification of reactive oxygen species.

    • Khalid N. Al-Zahrani
    • Ellen R. Langille
    • Daniel Schramek
    Article
  • Using LARES-2, LAGEOS and GRACE satellites, researchers measured Earth’s frame-dragging with unprecedented precision, strongly confirming general relativity, constraining alternative gravity theories, and improving measurements of Earth’s tides.

    • Ignazio Ciufolini
    • Antonio Paolozzi
    • Vahe Gurzadyan
    Article
  • An ATAC-seq-based approach is used to classify acute myeloid leukaemia (AML) into 16 epigenomic subgroups, and provides insight into the role of non-genetic mechanisms in determining pathogenesis, clinical behaviour and drug sensitivity in this disease.

    • Yotaro Ochi
    • Markus Liew-Littorin
    • Seishi Ogawa
    ArticleOpen Access
  • Diet shapes obesity-associated therapeutic responses to immune checkpoint inhibitors through gut microbial metabolism and host anti-tumour immunity, demonstrated in mouse custom-diet models and human-to-mouse fecal microbiota transplantation experiments.

    • Lysanne Desharnais
    • Anikka Swaby
    • Daniela F. Quail
    ArticleOpen Access
  • The EUROPE-IGM-ATLAS reveals spatiotemporal trends that characterize the changing geography of opportunity in Europe and its relationship with regional innovation.

    • Sarah McNamara
    • Guido Neidhöfer
    • Patrick Lehnert
    ArticleOpen Access

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