| ME | Middle English | |
| ME | Middle East | |
| ME | Middle Earth | |
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| ME | Maine (US postal abbreviation) | |
| ME | Mode Entry | |
| ME | Mobile Electronics | |
| ME | Mass Effect (game) | |
| ME | Managing Editor (newspaper industry) | |
| ME | Mirror's Edge (game) | |
| ME | Main Engine | |
| ME | Mail Early (slogan of post office) | |
| ME | Mechanical Engineer | |
| Me | Maître (French title) | |
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| ME | Model Engineer | |
| ME | Mobile Equipment | |
| ME | Mechanical Engineering | |
| ME | Master of Engineering (degree program) | |
| ME | Medical Education | |
| ME | Millennium Edition (Microsoft Windows) | |
| ME | Mid-Engine | |
| ME | Marriage Encounter | |
| ME | Maximum Effort | |
| ME | Mount Everest | |
| ME | Modern English | |
| ME | Maintenance Equipment | |
| ME | Spanish North Africa | |
| ME | Medical Examiner | |
| ME | Marine Engineer | |
| ME | Mechanical Equipment | |
| ME | Medway (postcode, United Kingdom) | |
| ME | Military Equipment | |
| ME | Moral Education (school subject) | |
| ME | Middle East Airlines (Air Liban, Lebanon, IATA airline code) | |
| ME | Manufacturing Engineering | |
| ME | Mission Employment (active phase of a mission or exercise) | |
| ME | Members Equity (Australian Bank) | |
| ME | Mutant Enemy | |
| ME | Motion Estimation (part of temporal redundancy coding technique used in digital television) | |
| ME | Messerschmitt (German aircraft manufacturer) | |
| ME | Melissa Etheridge (musician) | |
| ME | Ministry of Environment | |
| ME | Mitsubishi Electric (various locations) | |
| ME | Opening Information (filename extension; as in READ.ME) | |
| ME | Mobility Equipment | |
| ME | Macro Economics | |
| ME | Miscellaneous Equipment | |
| ME | Mechanized (welding) | |
| ME | Month Ending | |
| ME | Management Engineering | |
| ME | Ministria e Ekonomisë (Ministry of Economics, Albania) | |
| ME | Master Electrician | |
| ME | Mission Essential | |
| ME | Multi-Edit | |
| ME | Montreal Exchange | |
| ME | Microwave Engineering | |
| ME | Moniteur-Educateur (French: Teacher for Children with Difficulties) | |
| ME | Mission Économique (French: Economic Mission; various locations) | |
| ME | Ministério da Educação (Portuguese Ministry for Education) | |
| ME | Mission Evangélique (French) | |
| ME | Minimum Energy | |
| ME | Maximum Entropy | |
| ME | Main Etch (semiconductor gate etching) | |
| ME | Minimum Number of Errors | |
| ME | Messina, Sicilia (Italian province) | |
| ME | Materials Engineer | |
| ME | Michael Ellis (musician) | |
| Me | Methyl Group (-ch3) | |
| ME | Myalgic Encephalomyelitis | |
| ME | Muse Elf (gaming) | |
| ME | Muzzle Energy | |
| ME | Molecular Electronics | |
| ME | Main Effort | |
| ME | Micro-Economics | |
| ME | Mobiele Eenheid | |
| ME | Moneda Extranjera (Spanish: Foreign Currency) | |
| ME | Motion Executor | |
| ME | Metabolizable Energy | |
| ME | Marine Etablissement (Dutch) | |
| ME | Master's Degree in Engineering | |
| ME | Multiengine | |
| ME | Mental Endurance (Rifts RPG) | |
| ME | Medicina Estetica | |
| ME | Management Entity | |
| ME | Main Electronics | |
| ME | Marine Enlisted | |
| ME | Managed Entity | |
| ME | Minimum Evolution | |
| ME | Mapping Entity | |
| ME | Maintenance Entity (ITU-T) | |
| ME | Mirador Electoral (Guatemala) | |
| ME | Mechanical End | |
| ME | Maneuver Enhancement (Brigade) | |
| ME | Mental Excellence (education) | |
| ME | Margin Enhancement | |
| ME | Mature Equivalent | |
| ME | Mass Excavation (hydraulic excavators) | |
| ME | Molecular Emission | |
| ME | Military Special Delivery (Scott Catalogue prefix; philately) | |
| ME | Managed Element | |
| ME | Multi Equipos (Guatemala) | |
| ME | Moessbauer Effect | |
| ME | Microcode Engineer | |
| ME | Morristown and Erie Railway Incorporated | |
| ME | Multiple Exceptionalities (education) | |
| ME | Music Exhibitioner | |
| ME | Manpower Estimate | |
| ME | Maintenance/Methods Engineering | |
| ME | Missile Enable | |