{"id":"https://openalex.org/W3214775847","doi":"https://doi.org/10.1016/j.neuroimage.2021.118727","title":"Insights into human cerebral white matter maturation and degeneration across the adult lifespan","display_name":"Insights into human cerebral white matter maturation and degeneration across the adult lifespan","publication_year":2021,"publication_date":"2021-11-20","ids":{"openalex":"https://openalex.org/W3214775847","doi":"https://doi.org/10.1016/j.neuroimage.2021.118727","mag":"3214775847","pmid":"https://pubmed.ncbi.nlm.nih.gov/34813969"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2021.118727","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2021.118727","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neuroimage.2021.118727","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091866978","display_name":"Matthew Kiely","orcid":"https://orcid.org/0000-0002-2125-2843"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew Kiely","raw_affiliation_strings":["Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077684542","display_name":"Curtis Triebswetter","orcid":"https://orcid.org/0000-0002-1008-4880"},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Curtis Triebswetter","raw_affiliation_strings":["Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025141875","display_name":"Luis E. Cortina","orcid":"https://orcid.org/0000-0001-9173-5106"},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luis E. Cortina","raw_affiliation_strings":["Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053738993","display_name":"Zhaoyuan Gong","orcid":"https://orcid.org/0000-0001-6488-5424"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhaoyuan Gong","raw_affiliation_strings":["Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079922929","display_name":"Maryam Alsameen","orcid":null},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maryam H. Alsameen","raw_affiliation_strings":["Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070172780","display_name":"Richard G. Spencer","orcid":"https://orcid.org/0000-0001-7101-4328"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard G. Spencer","raw_affiliation_strings":["Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018530204","display_name":"Mustapha Bouhrara","orcid":"https://orcid.org/0000-0001-6184-669X"},"institutions":[{"id":"https://openalex.org/I4210136897","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210136897"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Mustapha Bouhrara","raw_affiliation_strings":["Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA. Electronic address: bouhraram@mail.nih.gov","Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA. Electronic address: bouhraram@mail.nih.gov","institution_ids":[]},{"raw_affiliation_string":"Laboratory of Clinical Investigation, National Institute on Aging, National Institutes of Health, Baltimore, 21224 MD, USA","institution_ids":["https://openalex.org/I4210136897","https://openalex.org/I1299303238"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5018530204"],"corresponding_institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210136897"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":5.3045,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.96312069,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"247","issue":null,"first_page":"118727","last_page":"118727"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11304","display_name":"Advanced Neuroimaging Techniques and Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10378","display_name":"Advanced MRI Techniques and Applications","score":0.9959999918937683,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":0.9941999912261963,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/white-matter","display_name":"White matter","score":0.8055273294448853},{"id":"https://openalex.org/keywords/myelin","display_name":"Myelin","score":0.7661741971969604},{"id":"https://openalex.org/keywords/diffusion-mri","display_name":"Diffusion MRI","score":0.7543656826019287},{"id":"https://openalex.org/keywords/magnetic-resonance-imaging","display_name":"Magnetic resonance imaging","score":0.5251733660697937},{"id":"https://openalex.org/keywords/sexual-dimorphism","display_name":"Sexual dimorphism","score":0.5224708318710327},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.47017329931259155},{"id":"https://openalex.org/keywords/neurodegeneration","display_name":"Neurodegeneration","score":0.42266613245010376},{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.4180160462856293},{"id":"https://openalex.org/keywords/human-brain","display_name":"Human brain","score":0.4115581810474396},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3487683832645416},{"id":"https://openalex.org/keywords/pathology","display_name":"Pathology","score":0.29724520444869995},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.2410341203212738},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.221804678440094},{"id":"https://openalex.org/keywords/central-nervous-system","display_name":"Central nervous system","score":0.20909076929092407},{"id":"https://openalex.org/keywords/radiology","display_name":"Radiology","score":0.10433617234230042}],"concepts":[{"id":"https://openalex.org/C2781192897","wikidata":"https://www.wikidata.org/wiki/Q822050","display_name":"White matter","level":3,"score":0.8055273294448853},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.7661741971969604},{"id":"https://openalex.org/C149550507","wikidata":"https://www.wikidata.org/wiki/Q899360","display_name":"Diffusion MRI","level":3,"score":0.7543656826019287},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.5251733660697937},{"id":"https://openalex.org/C105083479","wikidata":"https://www.wikidata.org/wiki/Q181497","display_name":"Sexual dimorphism","level":2,"score":0.5224708318710327},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.47017329931259155},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.42266613245010376},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4180160462856293},{"id":"https://openalex.org/C2777670902","wikidata":"https://www.wikidata.org/wiki/Q492038","display_name":"Human brain","level":2,"score":0.4115581810474396},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3487683832645416},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.29724520444869995},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2410341203212738},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.221804678440094},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.20909076929092407},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.10433617234230042},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001931","descriptor_name":"Brain Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008136","descriptor_name":"Longevity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009186","descriptor_name":"Myelin Sheath","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D066127","descriptor_name":"White Matter","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neuroimage.2021.118727","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2021.118727","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:34813969","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/34813969","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:doaj.org/article:362fa2e0c74d4dd2bdff893edc670afe","is_oa":true,"landing_page_url":"https://doaj.org/article/362fa2e0c74d4dd2bdff893edc670afe","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage, Vol 247, Iss , Pp 118727- (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8792239","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8792239","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuroimage","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2021.118727","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2021.118727","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":114,"referenced_works":["https://openalex.org/W1486803184","https://openalex.org/W1498301041","https://openalex.org/W1542408950","https://openalex.org/W1556823089","https://openalex.org/W1570294720","https://openalex.org/W1590047728","https://openalex.org/W1595872863","https://openalex.org/W1603992028","https://openalex.org/W1644155731","https://openalex.org/W1896870549","https://openalex.org/W1909181173","https://openalex.org/W1942882964","https://openalex.org/W1964724992","https://openalex.org/W1964997677","https://openalex.org/W1968388072","https://openalex.org/W1971082159","https://openalex.org/W1981000616","https://openalex.org/W1984199701","https://openalex.org/W1984742670","https://openalex.org/W1988945340","https://openalex.org/W1991211195","https://openalex.org/W1991725112","https://openalex.org/W1996189276","https://openalex.org/W1998185086","https://openalex.org/W2004006028","https://openalex.org/W2008655880","https://openalex.org/W2012524626","https://openalex.org/W2012664108","https://openalex.org/W2013219229","https://openalex.org/W2022092287","https://openalex.org/W2023485038","https://openalex.org/W2025047388","https://openalex.org/W2026812901","https://openalex.org/W2027102257","https://openalex.org/W2028037675","https://openalex.org/W2028382446","https://openalex.org/W2029713109","https://openalex.org/W2033685704","https://openalex.org/W2035309554","https://openalex.org/W2045137447","https://openalex.org/W2045632597","https://openalex.org/W2057434762","https://openalex.org/W2058965862","https://openalex.org/W2064457232","https://openalex.org/W2066309409","https://openalex.org/W2066517499","https://openalex.org/W2069243625","https://openalex.org/W2070468319","https://openalex.org/W2071881327","https://openalex.org/W2080737598","https://openalex.org/W2085918180","https://openalex.org/W2087242089","https://openalex.org/W2103374433","https://openalex.org/W2104542474","https://openalex.org/W2105848614","https://openalex.org/W2108038333","https://openalex.org/W2109181684","https://openalex.org/W2110065044","https://openalex.org/W2111947559","https://openalex.org/W2115424422","https://openalex.org/W2119980272","https://openalex.org/W2126587429","https://openalex.org/W2131940336","https://openalex.org/W2136040391","https://openalex.org/W2136340921","https://openalex.org/W2148971131","https://openalex.org/W2149305117","https://openalex.org/W2162723250","https://openalex.org/W2163097549","https://openalex.org/W2165020693","https://openalex.org/W2166312597","https://openalex.org/W2169459006","https://openalex.org/W2172095686","https://openalex.org/W2195198872","https://openalex.org/W2198243321","https://openalex.org/W2303207309","https://openalex.org/W2404056086","https://openalex.org/W2511297583","https://openalex.org/W2530170980","https://openalex.org/W2549276155","https://openalex.org/W2554389950","https://openalex.org/W2556951263","https://openalex.org/W2561810854","https://openalex.org/W2766024997","https://openalex.org/W2782273750","https://openalex.org/W2802493769","https://openalex.org/W2811485141","https://openalex.org/W2845606540","https://openalex.org/W2894848092","https://openalex.org/W2901255481","https://openalex.org/W2912691032","https://openalex.org/W2920455229","https://openalex.org/W2931590677","https://openalex.org/W2944868864","https://openalex.org/W2977883299","https://openalex.org/W2981306935","https://openalex.org/W2981752231","https://openalex.org/W3003348160","https://openalex.org/W3007450150","https://openalex.org/W3087738204","https://openalex.org/W3120261134","https://openalex.org/W3126596385","https://openalex.org/W3131444508","https://openalex.org/W3138184243","https://openalex.org/W3167505989","https://openalex.org/W3169907177","https://openalex.org/W3173015438","https://openalex.org/W3200269154","https://openalex.org/W4254204731","https://openalex.org/W6653559106","https://openalex.org/W6752982250","https://openalex.org/W6756465595","https://openalex.org/W6774678044","https://openalex.org/W6800989226"],"related_works":["https://openalex.org/W2044319992","https://openalex.org/W4240093285","https://openalex.org/W2371842353","https://openalex.org/W82441265","https://openalex.org/W2290911516","https://openalex.org/W3085773419","https://openalex.org/W4233341156","https://openalex.org/W1924523127","https://openalex.org/W2176413450","https://openalex.org/W1991680614"],"abstract_inverted_index":{"White":[0],"matter":[1],"(WM)":[2],"microstructural":[3,15,185],"properties":[4],"change":[5],"across":[6,257],"the":[7,87,90,96,116,203,219,222,235,258],"adult":[8,259],"lifespan":[9],"and":[10,52,74,79,110,140,145,221,228],"with":[11,143,154,162,193,199],"neuronal":[12],"diseases.":[13],"Understanding":[14],"changes":[16],"due":[17],"to":[18,22,45,99,113,122,168,174,196,245],"aging":[19],"is":[20],"paramount":[21],"distinguish":[23],"them":[24],"from":[25,241],"neuropathological":[26],"changes.":[27],"Conducted":[28],"on":[29],"a":[30,39,84,212,252],"large":[31],"cohort":[32],"of":[33,43,72,86,89,92,177,206,225],"147":[34],"cognitively":[35],"unimpaired":[36],"subjects,":[37],"spanning":[38],"wide":[40],"age":[41,144],"range":[42],"21":[44],"94":[46],"years,":[47],"our":[48,189,216,231],"study":[49],"evaluated":[50],"sex-":[51],"age-related":[53],"differences":[54,133,186],"in":[55,77,134,211],"WM":[56,178,226,237,249],"microstructure.":[57],"Specifically,":[58],"we":[59,104,130],"used":[60],"diffusion":[61],"tensor":[62],"imaging":[63,67],"(DTI)":[64],"magnetic":[65],"resonance":[66],"(MRI)":[68],"indices,":[69],"sensitive":[70],"measures":[71,210],"myelin":[73,80,97,138,169],"axonal":[75,141,182],"density":[76,142],"WM,":[78],"water":[81,93],"fraction":[82,88],"(MWF),":[83],"measure":[85],"signal":[91],"trapped":[94],"within":[95],"sheets,":[98],"probe":[100],"these":[101,208],"differences.":[102],"Furthermore,":[103,156,215],"examined":[105],"regional":[106],"correlations":[107],"between":[108],"MWF":[109],"DTI":[111,117,157],"indices":[112,158],"evaluate":[114],"whether":[115],"metrics":[118],"provide":[119],"information":[120],"complementary":[121],"MWF.":[123],"While":[124],"sexual":[125],"dimorphism":[126],"was,":[127],"overall,":[128],"nonsignificant,":[129],"observed":[131],"region-dependent":[132],"MWF,":[135,163,200],"that":[136,147,234],"is,":[137],"content,":[139],"found":[146],"both":[148],"exhibit":[149],"nonlinear,":[150],"but":[151],"distinct,":[152],"associations":[153,198],"age.":[155],"were":[159],"moderately":[160],"correlated":[161],"indicating":[164],"their":[165,194],"good":[166],"sensitivity":[167],"content":[170],"as":[171,173,181,243],"well":[172],"other":[175],"constituents":[176],"tissue":[179],"such":[180],"density.":[183],"The":[184],"captured":[187],"by":[188],"MRI":[190],"metrics,":[191],"along":[192],"weak":[195],"moderate":[197],"strongly":[201],"indicate":[202,233],"potential":[204],"value":[205],"combining":[207],"outcome":[209],"multiparametric":[213],"approach.":[214],"results":[217,232],"support":[218],"last-in-first-out":[220],"gain-predicts-loss":[223],"hypotheses":[224],"maturation":[227],"degeneration.":[229],"Indeed,":[230],"posterior":[236],"regions":[238],"are":[239],"spared":[240],"neurodegeneration":[242],"compared":[244],"anterior":[246],"regions,":[247],"while":[248],"myelination":[250],"follows":[251],"temporally":[253],"symmetric":[254],"time":[255],"course":[256],"life":[260],"span.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":15},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":10}],"updated_date":"2026-05-28T09:10:13.091523","created_date":"2025-10-10T00:00:00"}
