{"id":"https://openalex.org/W4414919967","doi":"https://doi.org/10.1016/j.neuroimage.2025.121509","title":"The intrinsic connectivity between the default mode and dorsal attention networks is an independent fMRI biomarker of Alzheimer's disease pathology burden","display_name":"The intrinsic connectivity between the default mode and dorsal attention networks is an independent fMRI biomarker of Alzheimer's disease pathology burden","publication_year":2025,"publication_date":"2025-10-07","ids":{"openalex":"https://openalex.org/W4414919967","doi":"https://doi.org/10.1016/j.neuroimage.2025.121509","pmid":"https://pubmed.ncbi.nlm.nih.gov/41061935"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroimage.2025.121509","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2025.121509","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.neuroimage.2025.121509","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Diego-Martin Lombardo","orcid":null},"institutions":[{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]},{"id":"https://openalex.org/I70900168","display_name":"Universit\u00e9 Savoie Mont Blanc","ror":"https://ror.org/04gqg1a07","country_code":"FR","type":"education","lineage":["https://openalex.org/I70900168"]}],"countries":["FR","US"],"is_corresponding":true,"raw_author_name":"Diego-Martin Lombardo","raw_affiliation_strings":["Universit\u00e9 Savoie Mont Blanc, Chamb\u00e9ry, France. Electronic address: diego-martin.lombardo-vera@univ-smb.fr","McLean Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, United States of America. Electronic address: diego.lombard@gmail.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Universit\u00e9 Savoie Mont Blanc, Chamb\u00e9ry, France. Electronic address: diego-martin.lombardo-vera@univ-smb.fr","institution_ids":["https://openalex.org/I70900168"]},{"raw_affiliation_string":"McLean Imaging Center, McLean Hospital, Department of Psychiatry, Harvard Medical School, United States of America. Electronic address: diego.lombard@gmail.com","institution_ids":["https://openalex.org/I2801148111"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057492639","display_name":"Christian F. Beckmann","orcid":"https://orcid.org/0000-0002-3373-3193"},"institutions":[{"id":"https://openalex.org/I145872427","display_name":"Radboud University Nijmegen","ror":"https://ror.org/016xsfp80","country_code":"NL","type":"education","lineage":["https://openalex.org/I145872427"]},{"id":"https://openalex.org/I4210101881","display_name":"Wellcome Centre for Integrative Neuroimaging","ror":"https://ror.org/0172mzb45","country_code":"GB","type":"facility","lineage":["https://openalex.org/I40120149","https://openalex.org/I4210101881","https://openalex.org/I87048295"]}],"countries":["GB","NL"],"is_corresponding":false,"raw_author_name":"Christian F Beckmann","raw_affiliation_strings":["Donders Institute, Radboud University, Nijmegen, Netherlands; Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Donders Institute, Radboud University, Nijmegen, Netherlands; Centre for Functional MRI of the Brain, Nuffield Department of Clinical Neurosciences, Wellcome Centre for Integrative Neuroimaging, University of Oxford, Oxford, UK","institution_ids":["https://openalex.org/I4210101881","https://openalex.org/I145872427"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801148111","https://openalex.org/I70900168"],"apc_list":{"value":3450,"currency":"USD","value_usd":3450},"apc_paid":{"value":3450,"currency":"USD","value_usd":3450},"fwci":4.1487,"has_fulltext":true,"cited_by_count":4,"citation_normalized_percentile":{"value":0.94428559,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":91,"max":99},"biblio":{"volume":"321","issue":null,"first_page":"121509","last_page":"121509"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neurocognitive","display_name":"Neurocognitive","score":0.8070999979972839},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.7458000183105469},{"id":"https://openalex.org/keywords/default-mode-network","display_name":"Default mode network","score":0.6783000230789185},{"id":"https://openalex.org/keywords/task-positive-network","display_name":"Task-positive network","score":0.6488999724388123},{"id":"https://openalex.org/keywords/cognitive-decline","display_name":"Cognitive decline","score":0.6240000128746033},{"id":"https://openalex.org/keywords/mechanism","display_name":"Mechanism (biology)","score":0.5146999955177307},{"id":"https://openalex.org/keywords/disease","display_name":"Disease","score":0.4830999970436096},{"id":"https://openalex.org/keywords/biomarker","display_name":"Biomarker","score":0.44839999079704285},{"id":"https://openalex.org/keywords/neuroimaging","display_name":"Neuroimaging","score":0.42570000886917114},{"id":"https://openalex.org/keywords/effects-of-sleep-deprivation-on-cognitive-performance","display_name":"Effects of sleep deprivation on cognitive performance","score":0.40560001134872437}],"concepts":[{"id":"https://openalex.org/C172467417","wikidata":"https://www.wikidata.org/wiki/Q1670397","display_name":"Neurocognitive","level":3,"score":0.8070999979972839},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.7458000183105469},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7301999926567078},{"id":"https://openalex.org/C141516989","wikidata":"https://www.wikidata.org/wiki/Q1182555","display_name":"Default mode network","level":3,"score":0.6783000230789185},{"id":"https://openalex.org/C47107517","wikidata":"https://www.wikidata.org/wiki/Q5298764","display_name":"Task-positive network","level":4,"score":0.6488999724388123},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.6240000128746033},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5569999814033508},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.5146999955177307},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4830999970436096},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.44839999079704285},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.42570000886917114},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.40560001134872437},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3562000095844269},{"id":"https://openalex.org/C67739388","wikidata":"https://www.wikidata.org/wiki/Q579471","display_name":"Cognitive reserve","level":4,"score":0.35569998621940613},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32350000739097595},{"id":"https://openalex.org/C6057870","wikidata":"https://www.wikidata.org/wiki/Q5141248","display_name":"Cognitive test","level":3,"score":0.3140999972820282},{"id":"https://openalex.org/C3017833866","wikidata":"https://www.wikidata.org/wiki/Q2397106","display_name":"Tau pathology","level":4,"score":0.31360000371932983},{"id":"https://openalex.org/C14216870","wikidata":"https://www.wikidata.org/wiki/Q3872","display_name":"Neuropsychology","level":3,"score":0.30730000138282776},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.30149999260902405},{"id":"https://openalex.org/C2777633098","wikidata":"https://www.wikidata.org/wiki/Q2736051","display_name":"Amyloid (mycology)","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C142853389","wikidata":"https://www.wikidata.org/wiki/Q744778","display_name":"Association (psychology)","level":2,"score":0.27900001406669617},{"id":"https://openalex.org/C45715564","wikidata":"https://www.wikidata.org/wiki/Q1292103","display_name":"Connectome","level":3,"score":0.2770000100135803},{"id":"https://openalex.org/C2781099131","wikidata":"https://www.wikidata.org/wiki/Q744385","display_name":"Temporal lobe","level":3,"score":0.27300000190734863},{"id":"https://openalex.org/C2777348757","wikidata":"https://www.wikidata.org/wiki/Q2346577","display_name":"Cortex (anatomy)","level":2,"score":0.2694999873638153},{"id":"https://openalex.org/C2780715579","wikidata":"https://www.wikidata.org/wiki/Q2603645","display_name":"Entorhinal cortex","level":3,"score":0.2669000029563904},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.26600000262260437},{"id":"https://openalex.org/C97820695","wikidata":"https://www.wikidata.org/wiki/Q387749","display_name":"Human Connectome Project","level":3,"score":0.2653000056743622},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.2644999921321869},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.26190000772476196},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.2556000053882599},{"id":"https://openalex.org/C2776925932","wikidata":"https://www.wikidata.org/wiki/Q1755122","display_name":"Neurodegeneration","level":3,"score":0.2535000145435333}],"mesh":[{"descriptor_ui":"D000082702","descriptor_name":"Default Mode Network","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000082702","descriptor_name":"Default Mode Network","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000082702","descriptor_name":"Default Mode Network","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000082702","descriptor_name":"Default Mode Network","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000082702","descriptor_name":"Default Mode Network","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000082702","descriptor_name":"Default Mode Network","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001288","descriptor_name":"Attention","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001288","descriptor_name":"Attention","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008279","descriptor_name":"Magnetic Resonance Imaging","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D009415","descriptor_name":"Nerve Net","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049268","descriptor_name":"Positron-Emission Tomography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D060825","descriptor_name":"Cognitive Dysfunction","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1016/j.neuroimage.2025.121509","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2025.121509","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},{"id":"pmid:41061935","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41061935","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":null},{"id":"pmh:oai:repository.ubn.ru.nl:2066/325359","is_oa":true,"landing_page_url":"https://hdl.handle.net/2066/325359","pdf_url":"https://repository.ubn.ru.nl//bitstream/handle/2066/325359/325359.pdf","source":{"id":"https://openalex.org/S4306401067","display_name":"Radboud Repository (Radboud University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I145872427","host_organization_name":"Radboud University Nijmegen","host_organization_lineage":["https://openalex.org/I145872427"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article / Letter to editor"},{"id":"pmh:oai:doaj.org/article:00272d7c1c2b41a182048946ad9e1da9","is_oa":true,"landing_page_url":"https://doaj.org/article/00272d7c1c2b41a182048946ad9e1da9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"NeuroImage, Vol 321, Iss , Pp 121509- (2025)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1016/j.neuroimage.2025.121509","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.neuroimage.2025.121509","pdf_url":null,"source":{"id":"https://openalex.org/S103225281","display_name":"NeuroImage","issn_l":"1053-8119","issn":["1053-8119","1095-9572"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"NeuroImage","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309697","display_name":"Alzheimer's Disease Neuroimaging Initiative","ror":"https://ror.org/01j20wc74"},{"id":"https://openalex.org/F4320314997","display_name":"Strong","ror":"https://ror.org/041vyzr56"},{"id":"https://openalex.org/F4320338487","display_name":"DoD Alzheimer's Disease Neuroimaging Initiative","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W1760829075","https://openalex.org/W1963568158","https://openalex.org/W1977714477","https://openalex.org/W1992265439","https://openalex.org/W1993023011","https://openalex.org/W2020044743","https://openalex.org/W2022381144","https://openalex.org/W2025009638","https://openalex.org/W2045758998","https://openalex.org/W2047453615","https://openalex.org/W2053187227","https://openalex.org/W2096672020","https://openalex.org/W2097982135","https://openalex.org/W2103025655","https://openalex.org/W2113506774","https://openalex.org/W2117340355","https://openalex.org/W2117621792","https://openalex.org/W2133649359","https://openalex.org/W2136573752","https://openalex.org/W2147401077","https://openalex.org/W2151721316","https://openalex.org/W2165758561","https://openalex.org/W2166536611","https://openalex.org/W2169508236","https://openalex.org/W2298073589","https://openalex.org/W2325305575","https://openalex.org/W2416451487","https://openalex.org/W2559169952","https://openalex.org/W2567460568","https://openalex.org/W2593796352","https://openalex.org/W2613800048","https://openalex.org/W2626001339","https://openalex.org/W2743373469","https://openalex.org/W2743773590","https://openalex.org/W2763403209","https://openalex.org/W2766125374","https://openalex.org/W2791135917","https://openalex.org/W2896341253","https://openalex.org/W2917754423","https://openalex.org/W2920509382","https://openalex.org/W2980552311","https://openalex.org/W2989855650","https://openalex.org/W2991962829","https://openalex.org/W2998692653","https://openalex.org/W3082963664","https://openalex.org/W3097047910","https://openalex.org/W3165858085","https://openalex.org/W3197362046","https://openalex.org/W3206523653","https://openalex.org/W4286111466","https://openalex.org/W4307112472","https://openalex.org/W4313992148","https://openalex.org/W4385948631","https://openalex.org/W4402457300","https://openalex.org/W4407018266"],"related_works":[],"abstract_inverted_index":{"\u2022":[0,16,32,49],"fMRI":[1],"DMN-DAN":[2,19,33,50,181,187,209,236],"connecitivty":[3],"predicts":[4],"Alzheimer's":[5,26,58,69],"pathology":[6,45,84,104,149,191,264,294],"burden":[7],"independent":[8,261,288],"of":[9,18,29,43,65,246,258,262,267,281,285,289,298],"brain":[10,82,100,222],"PET":[11,161,198],"tau-load,":[12],"and":[13,60,142,163,201,221,238,251,265,295],"cognitive":[14,23,37,91,126,164,173,202,212,228,239,259,270,273,299,303],"reserve":[15],"Attenuation":[17],"anticorrelation":[20,34,136,188,210,237,248],"links":[21],"to":[22,110,269],"impairment":[24,174],"in":[25,68,77,93,128,151,193],"disease":[27,70],"independetn":[28],"clinical":[30],"status":[31],"correlates":[35],"with":[36,102,255],"decline":[38,92,127,271],"controled":[39],"by":[40,197,217],"the":[41,74,78,86,118,135,138,152,186,233,244,247,279],"efects":[42],"traditional":[44],"markers":[46],"like":[47],"p-tau.":[48],"connectivity":[51],"offers":[52],"an":[53,106,207,282],"potential":[54],"early":[55,61],"biomarker":[56],"for":[57],"progression":[59],"diagnosis.":[62],"The":[63],"mechanism":[64,257,284],"neurocognitive":[66,286],"failure":[67],"remains":[71],"obscure.":[72],"While":[73],"mainstream":[75],"hypothesis":[76],"field":[79],"posits":[80],"that":[81,89,117,185,206,243],"tau":[83,223,263],"is":[85,253],"only":[87],"process":[88],"drives":[90],"AD,":[94,194],"other":[95],"complementary":[96],"mechanisms":[97],"link":[98],"vascular":[99],"lesions":[101],"beta-amyloid":[103],"as":[105,195,302],"important":[107],"factor":[108],"leading":[109],"neurodegeneration.":[111],"Recently,":[112],"it":[113],"was":[114,215],"also":[115,277],"proposed":[116],"brain's":[119],"network's":[120],"functional":[121],"imbalance":[122],"could":[123],"primarily":[124],"drive":[125],"neurodegenerative":[129],"diseases.":[130],"Here,":[131],"we":[132,170],"investigated":[133,171],"whether":[134,172],"between":[137,190,235,249],"default":[139],"mode":[140],"(DMN)":[141],"dorsal":[143],"attention":[144],"networks":[145],"(DAN)":[146],"reveals":[147],"different":[148],"burdens":[150,192],"AD":[153],"spectrum.":[154],"We":[155,183,204,241],"grouped":[156],"individuals":[157],"based":[158,178],"on":[159,179],"their":[160],"amyloid":[162,199],"status.":[165],"Using":[166],"cross-validated":[167],"regression":[168],"models,":[169],"can":[175],"be":[176],"predicted":[177,211],"rs-fMRI":[180],"anticorrelation.":[182],"found":[184,205],"differentiates":[189],"quantified":[196],"imaging":[200],"performance.":[203],"attenuated":[208],"decline,":[213,300],"which":[214],"controlled":[216],"sex,":[218],"age,":[219],"education,":[220],"pathology.":[224],"Education":[225],"level,":[226],"measuring":[227],"reserve,":[229],"did":[230],"not":[231],"modulate":[232],"association":[234],"decline.":[240],"demonstrate":[242],"attenuation":[245],"DMN":[250],"DAN":[252],"associated":[254],"a":[256],"dysfunction":[260],"proxies":[266],"resilience":[268],"or":[272],"reserve.":[274,304],"Our":[275],"results":[276],"suggest":[278],"existence":[280],"alternative":[283],"breakdown":[287],"advanced":[290],"medial":[291],"temporal":[292],"cortex":[293],"protective":[296],"factors":[297],"such":[301]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":1}],"updated_date":"2026-06-18T10:00:31.954636","created_date":"2025-10-10T00:00:00"}