FOXP2

FOXP2
Strwythurau PDB Human UniProt search: PDBe RCSB Rhestr o ddynodwyr PDB 2AS5, 2A07
Dynodwyr
Cyfenwau	FOXP2, CAGH44, SPCH1, TNRC10, forkhead box P2
Dynodwyr allanol	OMIM: 605317 HomoloGene: 33482 GeneCards: FOXP2
Patrwm RNA pattern Rhagor o gyfeiriadau
Ontoleg y genyn Gweithrediad moleciwlaidd • DNA binding • sequence-specific DNA binding • protein homodimerization activity • GO:0001131, GO:0001151, GO:0001130, GO:0001204 DNA-binding transcription factor activity • metal ion binding • GO:0000980 RNA polymerase II cis-regulatory region sequence-specific DNA binding • GO:0001948, GO:0016582 protein binding • protein heterodimerization activity • identical protein binding • GO:0001200, GO:0001133, GO:0001201 DNA-binding transcription factor activity, RNA polymerase II-specific • androgen receptor binding • GO:0001078, GO:0001214, GO:0001206 DNA-binding transcription repressor activity, RNA polymerase II-specific Cydrannau o'r gell • cnewyllyn cell Prosesau biolegol • positive regulation of epithelial cell proliferation involved in lung morphogenesis • GO:0009373 regulation of transcription, DNA-templated • lung development • positive regulation of epithelial cell proliferation • GO:1901227 negative regulation of transcription by RNA polymerase II • post-embryonic development • transcription, DNA-templated • cerebellum development • putamen development • vocal learning • positive regulation of mesenchymal cell proliferation • smooth muscle tissue development • cerebral cortex development • caudate nucleus development • camera-type eye development • lung alveolus development • righting reflex • GO:0045996 negative regulation of transcription, DNA-templated • skeletal muscle tissue development • forebrain development • response to testosterone • innate vocalization behavior • anatomical structure morphogenesis • cell differentiation • growth Sources:Amigo / QuickGO
Orthologau
Species	Bod dynol	Llygoden
Entrez	93986	n/a
Ensembl	ENSG00000128573	n/a
UniProt	O15409 Q75MZ5 Q0PRL4 Q8N6B6	n/a
RefSeq (mRNA)	NM_001172766 NM_001172767 NM_014491 NM_148898 NM_148899 NM_148900	n/a
RefSeq (protein)	NP_001166237 NP_001166238 NP_055306 NP_683696 NP_683697 NP_683698 NP_001166237.1 NP_683697.2	n/a
Lleoliad (UCSC)	n/a	n/a
PubMed search		n/a
Wicidata
Gweld/Golygu Bod dynol

Protein sy'n cael ei godio yn y corff dynol gan y genyn FOXP2 yw FOXP2 a elwir hefyd yn Forkhead/winged helix transcription factor, FOXP2 protein, Forkhead box P2, isoform CRA_a a Forkhead box P2 (Saesneg). Segment o DNA yw'r genyn, sy'n amgodio ffwythiant arbennig. Mae'r genyn yma wedi ei leoli ar yr edefyn blaen o gromosom dynol 7, band 7q31.1.

Cyfystyron

Yn aml mae gan enynnau lawer o gyfystyron. Mae hyn oherwydd eu bod yn aml yn cael eu darganfod gan nifer o bobl mewn cyd-destunau gwahanol heb wybod mai'r un genynnau oeddyn nhw. Hefyd mae gan wahanol gymunedau gwyddonol safonau gwahanol ar gyfer enwi genynnau. Dyma restr o gyfystyron ar gyfer y genyn FOXP2.

• SPCH1
• CAGH44
• TNRC10

Llyfryddiaeth

• "Segregating polymorphisms of FOXP2 are associated with measures of inner speech, speech fluency and strength of handedness in a healthy population. ". Brain Lang. 2017. PMID 28609679.
• "The FOXP2 forkhead domain binds to a variety of DNA sequences with different rates and affinities. ". J Biochem. 2017. PMID 28104810.
• "FOXP2 variants in 14 individuals with developmental speech and language disorders broaden the mutational and clinical spectrum. ". J Med Genet. 2017. PMID 27572252.
• FOXP2-Related Speech and Language Disorders. 1993. PMID 27336128.
• "Common Genetic Variants in FOXP2 Are Not Associated with Individual Differences in Language Development.". PLoS One. 2016. PMID 27064276.