close
Jump to content

Howard Y. Chang

From Wikipedia, the free encyclopedia
Howard Y. Chang
張元豪
Born
Chang Yuan-hao

(1972-01-11) January 11, 1972 (age 54)
Taipei, Taiwan
EducationHarvard University (BA, MD)
Massachusetts Institute of Technology (PhD)
Known forLong non-coding RNA
FatherChang Chau-hsiung
Scientific career
FieldsMolecular biology
InstitutionsStanford University
ThesisMolecular studies of Fas signaling and programmed cell death (1998)
David Baltimore
Other academic advisors
Chinese name
Traditional Chinese張元豪
Simplified Chinese张元豪
Transcriptions
Standard Mandarin
Hanyu PinyinZhang Yuan-Hao
Bopomofoㄓㄤ ㄩㄢˊ ㄏㄠˊ
Wade–GilesChang Yuan-Hao

Howard Yuan-hao Chang (Chinese: 張元豪; pinyin: Zhāng Yuánháo; born January 11, 1972) is a Taiwanese-American physician-scientist and molecular biologist. He is the Virginia and D. K. Ludwig Professor of Cancer Research at Stanford University, where he is also a joint professor of dermatology, genetics, and pathology at the Stanford University School of Medicine.

Since 2024, Chang has been the senior vice president of research and chief scientific officer of Amgen.[1] He is also a principal investigator at the Howard Hughes Medical Institute.[2] He is best known for his research on long non-coding RNAs.[3]

Early life and education

[edit]

Chang was born in Taipei, Taiwan, on January 11, 1972, to a family of Taiwanese physicians.[4] He is the son of Taiwanese physician and politician Chang Chau-hsiung, a former chair of the People First Party.[5] When he was twelve years old, Chang moved with his mother and younger brother to Southern California.[6]

Chang graduated summa cum laude from Harvard University with a Bachelor of Arts in biochemistry in 1994.[7] As an undergraduate at Harvard College, he worked in the laboratory of biochemist Christopher T. Walsh.[6] He then earned his Ph.D. in biology from the Massachusetts Institute of Technology (MIT) under Nobel laureate David Baltimore in 1998.[7]

In 2000, Chang earned his Doctor of Medicine (M.D.) from Harvard Medical School.[7] As a medical student at Harvard, Chang was a member of the Harvard–MIT Program in Health Sciences and Technology,[8] and won the medical school's Leon Reznick Memorial Prize for excellence in research.[9]

Academic career

[edit]

After receiving his M.D., Chang was a postdoctoral fellow at Stanford under Patrick O. Brown from 2000 to 2004. He simultaneously completed his residency in dermatology at the Stanford University School of Medicine from 2001 to 2004.[7]

After starting his own lab, Chang's group discovered unexpected transcriptional activity for noncoding DNA and identified HOTAIR which further confirmed the importance of long non-coding RNAs.[10][6] More recently, his group has reported multiple discoveries related to mechanisms and functional roles of extrachromosomal DNA in cancer pathogenesis.[11]

Chang is a co-inventor of ATAC-seq, a widely-used epigenomic method introduced in 2013 in collaboration with the lab of William J. Greenleaf.[12][13][14][15]

Awards

[edit]

References

[edit]
  1. ↑ "Amgen taps Stanford's Howard Chang to take CSO reins from R&D chief Jay Bradner". Fiercebiotech.com. Retrieved 21 November 2024.
  2. ↑ "Howard Y. Chang, MD, PhD". Howard Hughes Medical Institute. Retrieved January 10, 2020.
  3. ↑ "Howard Y. Chang, MD PhD". Stanford University Neurosciences Institute.
  4. ↑ "Curriculum Vitae: Howard Y. Chang". Stanford University. Archived from the original on December 5, 2005. Retrieved July 27, 2018.
  5. ↑ "中研院院士解開「自體免疫疾病」之謎！張昭雄之子張元豪：罪魁禍首是RNA分子「Xist」". The Storm Media (in Chinese (Taiwan)). 4 February 2024. Retrieved 12 October 2024.
  6. 1 2 3 Ahmed, Farooq (13 April 2021). "Profile of Howard Y. Chang". Proceedings of the National Academy of Sciences. 118 (15) e2104246118. Bibcode:2021PNAS..11804246A. doi:10.1073/pnas.2104246118. PMC 8053961. PMID 33833062.
  7. 1 2 3 4 "Curriculum Vitae: Howard Y. Chang". Stanford University. 2017. Retrieved 28 March 2026.
  8. ↑ "Howard Y. Chang, MD PhD". Stanford University. Retrieved July 27, 2018.
  9. ↑ "2000 September HST Newsletter" (PDF). Hst.mit.edu. June 25, 2026.
  10. ↑ Rinn, John L.; Kertesz, Michael; Wang, Jordon K.; Squazzo, Sharon L.; Xu, Xiao; Brugmann, Samantha A.; Goodnough, L. Henry; Helms, Jill A.; Farnham, Peggy J.; Segal, Eran; Chang, Howard Y. (June 2007). "Functional Demarcation of Active and Silent Chromatin Domains in Human HOX Loci by Noncoding RNAs". Cell. 129 (7): 1311–1323. doi:10.1016/j.cell.2007.05.022. PMC 2084369. PMID 17604720.
  11. ↑ Yan, Xiaowei; Mischel, Paul; Chang, Howard Y. (26 February 2024). "Extrachromosomal DNA in cancer". Nature Reviews Cancer.
  12. ↑ Buenrostro JD, Giresi PG, Zaba LC, Chang HY, Greenleaf WJ (October 6, 2013). "Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position". Nature Methods. 10 (12): 1213–1218. doi:10.1038/nmeth.2688. PMC 3959825. PMID 24097267.
  13. ↑ US patent US10619207B2, "Transposition into native chromatin for personal epigenomics", issued April 14, 2020, assigned to The Board of Trustees of the Leland Stanford Junior University
  14. ↑ "ATAC-Seq (assay for transposase-accessible chromatin with sequencing)". Illumina. Retrieved October 26, 2025.
  15. ↑ "Complete Guide to Understanding and Using ATAC-Seq". Active Motif. Retrieved October 26, 2025.
  16. ↑ "2018 NAS Award in Molecular Biology". National Academy of Sciences. Retrieved January 10, 2020.
  17. ↑ "Howard Y. Chang". American Academy of Arts & Sciences. Retrieved 2021-01-09.
  18. ↑ Foundation, King Faisal (Jan 10, 2024). "Distinguished Scientists with Breakthroughs in Gene Therapy for Neuromuscular Diseases, and Revolutionary RNA Discoveries, Announced as King Faisal Prize Laureates in Medicine & Science". Globenewswire.com. Retrieved Jun 25, 2026.
  19. ↑ "Stanley J. Korsmeyer Award: 2024 Howard Y. Chang". The American Society for Clinical Investigation. 2024-02-15. Retrieved 2025-03-10.
  20. ↑ "2025 Recipient". Albanymed.org. Retrieved Jun 25, 2026.
Retrieved from "https://en.wikipedia.org/w/index.php?title=Howard_Y._Chang&oldid=1361081607"