PRKAA1

PRKAA1
ساختارهای موجود PDB جستجوی هم‌ساخت‌شناسی: PDBe RCSB فهرست شناسه‌های PDB 4RED, 4RER, 4REW, 5EZV
معین‌کننده‌ها
نام‌های دیگر	PRKAA1, AMPK, AMPKa1, Protein kinase, AMP-activated, alpha 1, protein kinase AMP-activated catalytic subunit alpha 1
شناسه‌های بیرونی	OMIM: 602739; MGI: 2145955; HomoloGene: 49590; GeneCards: PRKAA1; OMA:PRKAA1 - orthologs
عدد EC	2.7.11.26
موقعیت ژن (انسان) کروموزوم کروموزوم ۵ (انسان) نوار ناموجود شروع 40,759,379 bp پایان 40,798,374 bp
موقعیت ژن (موش) کروموزوم کروموزوم ۱۵ (موش) نوار 15|15 A1 شروع 5,173,343 bp پایان 5,211,380 bp
الگوی گسترش RNA Bgee انسان موش (هم‌ساخت) بیشترین بیان در gastric mucosa stromal cell of endometrium epithelium of colon tibial arteries body of pancreas Descending thoracic aorta بیشترین بیان در epithelium of small intestine mammillary body white adipose tissue ventromedial nucleus medial vestibular nucleus lateral hypothalamus داده‌های بیشتر بیان BioGPS داده‌های بیشتر بیان
هستی‌شناسی ژن عملکرد ملکولی transferase activity nucleotide binding protein kinase activity cAMP-dependent protein kinase activity [acetyl-CoA carboxylase kinase activity] AMP-activated protein kinase activity histone serine kinase activity chromatin binding metal ion binding kinase activity protein serine/threonine kinase activity tau-protein kinase activity protein C-terminus binding پیوند پروتئینی [hydroxymethylglutaryl-CoA reductase (NADPH) kinase activity] ATP binding tau protein binding ترکیبات سلولی nucleotide-activated protein kinase complex apical plasma membrane نوکلئوپلاسم هسته یاخته سیتوپلاسم سیتوزول nuclear speck intracellular anatomical structure آسه دندریت protein-containing complex soma فرایند زیستی cellular response to organonitrogen compound steroid metabolic process cellular response to glucose starvation sterol biosynthetic process lipid biosynthetic process regulation of transcription, DNA-templated response to hypoxia cellular response to ethanol glucose homeostasis positive regulation of skeletal muscle tissue development protein heterooligomerization rhythmic process فسفرگیری سوخت‌وساز لیپید regulation of vesicle-mediated transport negative regulation of apoptotic process cholesterol metabolic process مسیر پیام‌رسانی وینت response to activity Synthesis saturated fatty acids by metabolites transcription, DNA-templated cellular response to prostaglandin E stimulus خودخواری protein phosphorylation negative regulation of TOR signaling cold acclimation positive regulation of gene expression response to camptothecin fatty acid biosynthetic process fatty acid homeostasis regulation of circadian rhythm fatty acid oxidation regulation of peptidyl-serine phosphorylation cellular response to nutrient levels positive regulation of cell population proliferation negative regulation of glucosylceramide biosynthetic process glucose metabolic process positive regulation of cholesterol biosynthetic process response to caffeine cholesterol biosynthetic process negative regulation of lipid catabolic process واکنش به پرتو گاما macroautophagy واکنش به فرابنفش positive regulation of glycolytic process response to hydrogen peroxide cellular response to hypoxia ورارسانی پیام cellular response to hydrogen peroxide steroid biosynthetic process regulation of signal transduction by p53 class mediator positive regulation of autophagy CAMKK-AMPK signaling cascade regulation of macroautophagy chromatin organization positive regulation of mitochondrial transcription positive regulation of protein targeting to mitochondrion negative regulation of gene expression cellular response to oxidative stress intracellular signal transduction negative regulation of insulin receptor signaling pathway motor behavior regulation of stress granule assembly neuron cellular homeostasis regulation of microtubule cytoskeleton organization cellular response to calcium ion cellular response to glucose stimulus energy homeostasis positive regulation of protein localization negative regulation of tubulin deacetylation positive regulation of peptidyl-lysine acetylation منابع: آمیگو / کوئیک‌گو
هم‌ساخت‌شناسی گونه‌ها انسان موش Entrez 5562 105787 Ensembl ENSG00000132356 ENSMUSG00000050697 UniProt Q13131 Q5EG47 RefSeq (mRNA) NM_006251 NM_206907 NM_001013367 NM_001355640 RefSeq (پروتئین) NP_006242 NP_996790 NP_001341957 NP_001341958 NP_001341963 NP_001341964 NP_001341965 NP_001341966 NP_001013385 NP_001342569 موقعیت (UCSC) Chr 5: 40.76 – 40.8 Mb Chr 15: 5.17 – 5.21 Mb جستجوی PubMed
ویکی‌داده
مشاهده/ویرایش انسان مشاهده/ویرایش موش

زیرواحد آلفا-۱ کاتالیتیک پروتئین کیناز فعال‌شده با ۵'-آدنوزین مونوفسفات (انگلیسی: 5'-AMP-activated protein kinase catalytic subunit alpha-1) که با نام «AMPKa1» هم شناخته می‌شود، یک پروتئین است که در انسان توسط ژن «PRKAA1» کُدگذاری می‌شود.

این پروتئین متعلق به خانوادهٔ پروتئین کینازهای اختصاصی سرین/ترئونین است. ثابت شده که طی پیرایش دگرسان، نسخهٔ‌های رونویسی مختلفی از این ژن که ایزوفرم‌های گوناگونی را پدیدمی‌آوردند، به وجود می‌آید.

این پروتئین با مولکول TSC2 تعامل پروتئین-پروتئین دارد.

منابع

• مشارکت‌کنندگان ویکی‌پدیا. «Protein kinase, AMP-activated, alpha 1». در دانشنامهٔ ویکی‌پدیای انگلیسی، بازبینی‌شده در ۱۶ اکتبر ۲۰۲۲.

برای مطالعهٔ بیشتر

• Munday MR, Campbell DG, Carling D, Hardie DG (1988). "Identification by amino acid sequencing of three major regulatory phosphorylation sites on rat acetyl-CoA carboxylase". Eur. J. Biochem. 175 (2): 331–8. doi:10.1111/j.1432-1033.1988.tb14201.x. PMID 2900138.
• Woods A, Cheung PC, Smith FC, et al. (1996). "Characterization of AMP-activated protein kinase beta and gamma subunits. Assembly of the heterotrimeric complex in vitro". J. Biol. Chem. 271 (17): 10282–90. doi:10.1074/jbc.271.48.30517. PMID 8626596.
• Hawley SA, Davison M, Woods A, et al. (1996). "Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase". J. Biol. Chem. 271 (44): 27879–87. doi:10.1074/jbc.271.44.27879. PMID 8910387.
• Stapleton D, Woollatt E, Mitchelhill KI, et al. (1997). "AMP-activated protein kinase isoenzyme family: subunit structure and chromosomal location". FEBS Lett. 409 (3): 452–6. doi:10.1016/S0014-5793(97)00569-3. PMID 9224708. S2CID 39329574.
• Velasco G, Gómez del Pulgar T, Carling D, Guzmán M (1998). "Evidence that the AMP-activated protein kinase stimulates rat liver carnitine palmitoyltransferase I by phosphorylating cytoskeletal components". FEBS Lett. 439 (3): 317–20. doi:10.1016/S0014-5793(98)01400-8. PMID 9845345. S2CID 29493620.
• Crute BE, Seefeld K, Gamble J, et al. (1999). "Functional domains of the alpha1 catalytic subunit of the AMP-activated protein kinase". J. Biol. Chem. 273 (52): 35347–54. doi:10.1074/jbc.273.52.35347. PMID 9857077.
• da Silva Xavier G, Leclerc I, Salt IP, et al. (2000). "Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression". Proc. Natl. Acad. Sci. U.S.A. 97 (8): 4023–8. Bibcode:2000PNAS...97.4023D. doi:10.1073/pnas.97.8.4023. PMC 18135. PMID 10760274.
• Hallows KR, Raghuram V, Kemp BE, et al. (2000). "Inhibition of cystic fibrosis transmembrane conductance regulator by novel interaction with the metabolic sensor AMP-activated protein kinase". J. Clin. Invest. 105 (12): 1711–21. doi:10.1172/JCI9622. PMC 378514. PMID 10862786.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Chen ZP, McConell GK, Michell BJ, et al. (2000). "AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation". Am. J. Physiol. Endocrinol. Metab. 279 (5): E1202–6. doi:10.1152/ajpendo.2000.279.5.E1202. PMID 11052978. S2CID 13387968.
• Blázquez C, Geelen MJ, Velasco G, Guzmán M (2001). "The AMP-activated protein kinase prevents ceramide synthesis de novo and apoptosis in astrocytes". FEBS Lett. 489 (2–3): 149–53. doi:10.1016/S0014-5793(01)02089-0. PMID 11165240. S2CID 35584617.
• Diggle TA, Subkhankulova T, Lilley KS, et al. (2001). "Phosphorylation of elongation factor-2 kinase on serine 499 by cAMP-dependent protein kinase induces Ca2+/calmodulin-independent activity". Biochem. J. 353 (Pt 3): 621–6. doi:10.1042/0264-6021:3530621. PMC 1221608. PMID 11171059.
• Wang X, Li W, Williams M, et al. (2001). "Regulation of elongation factor 2 kinase by p90(RSK1) and p70 S6 kinase". EMBO J. 20 (16): 4370–9. doi:10.1093/emboj/20.16.4370. PMC 125559. PMID 11500364.
• Xi X, Han J, Zhang JZ (2001). "Stimulation of glucose transport by AMP-activated protein kinase via activation of p38 mitogen-activated protein kinase". J. Biol. Chem. 276 (44): 41029–34. doi:10.1074/jbc.M102824200. PMID 11546797.
• Fryer LG, Foufelle F, Barnes K, et al. (2002). "Characterization of the role of the AMP-activated protein kinase in the stimulation of glucose transport in skeletal muscle cells". Biochem. J. 363 (Pt 1): 167–74. doi:10.1042/0264-6021:3630167. PMC 1222463. PMID 11903059.
• Yang CS, Weiner H (2002). "Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol". Arch. Biochem. Biophys. 400 (1): 105–10. doi:10.1006/abbi.2002.2778. PMID 11913976.
• Bolster DR, Crozier SJ, Kimball SR, Jefferson LS (2002). "AMP-activated protein kinase suppresses protein synthesis in rat skeletal muscle through down-regulated mammalian target of rapamycin (mTOR) signaling". J. Biol. Chem. 277 (27): 23977–80. doi:10.1074/jbc.C200171200. PMID 11997383.
• Esumi H, Izuishi K, Kato K, et al. (2002). "Hypoxia and nitric oxide treatment confer tolerance to glucose starvation in a 5'-AMP-activated protein kinase-dependent manner". J. Biol. Chem. 277 (36): 32791–8. doi:10.1074/jbc.M112270200. PMID 12091379.
• Horman S, Browne G, Krause U, et al. (2003). "Activation of AMP-activated protein kinase leads to the phosphorylation of elongation factor 2 and an inhibition of protein synthesis". Curr. Biol. 12 (16): 1419–23. doi:10.1016/S0960-9822(02)01077-1. PMID 12194824. S2CID 9865400.