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Comment
. 2002 Jan 1;538(Pt 1):1.
doi: 10.1113/jphysiol.2001.013372.

Orthostatic intolerance after space flight

Wouter Wieling  1 , John R Halliwill, John M Karemaker
Affiliations
Comment

Orthostatic intolerance after space flight

Wouter Wieling et al. J Physiol. .

Abstract

Physiologists have always been challenged by the adjustments of the human body to hostile environments. The set of papers in this issue of The Journal of Physiology (Cox et al. 2002; Ertl et al. 2002; Levine et al. 2002) fits into the tradition of the study of human responses to extreme physical circumstances. The Neurolab project represents a huge undertaking that required major contributions from many different collaborators, and the coordination of efforts at different institutions. The studies succeeded because of the dedication and years of work of the astronauts involved. The manuscripts present the fundamental findings from the first direct recordings of sympathetic vasoconstrictor nerves and noradrenaline kinetics in humans during microgravity. Despite the difficulties of performing such measurements on the space shuttle and the small numbers of astronauts involved, unique data are set forth that represent a major advance in our understanding of the physiology of space flight.

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Comment on

  • Influence of microgravity on astronauts' sympathetic and vagal responses to Valsalva's manoeuvre.
    Cox JF, Tahvanainen KU, Kuusela TA, Levine BD, Cooke WH, Mano T, Iwase S, Saito M, Sugiyama Y, Ertl AC, Biaggioni I, Diedrich A, Robertson RM, Zuckerman JH, Lane LD, Ray CA, White RJ, Pawelczyk JA, Buckey JC Jr, Baisch FJ, Blomqvist CG, Robertson D, Eckberg DL; New Collective Author. Cox JF, et al. J Physiol. 2002 Jan 1;538(Pt 1):309-20. doi: 10.1113/jphysiol.2001.012574. J Physiol. 2002. PMID: 11773338 Free PMC article.
  • Human muscle sympathetic nerve activity and plasma noradrenaline kinetics in space.
    Ertl AC, Diedrich A, Biaggioni I, Levine BD, Robertson RM, Cox JF, Zuckerman JH, Pawelczyk JA, Ray CA, Buckey JC Jr, Lane LD, Shiavi R, Gaffney FA, Costa F, Holt C, Blomqvist CG, Eckberg DL, Baisch FJ, Robertson D; New Collective Author. Ertl AC, et al. J Physiol. 2002 Jan 1;538(Pt 1):321-9. doi: 10.1113/jphysiol.2001.012576. J Physiol. 2002. PMID: 11773339 Free PMC article.
  • Human muscle sympathetic neural and haemodynamic responses to tilt following spaceflight.
    Levine BD, Pawelczyk JA, Ertl AC, Cox JF, Zuckerman JH, Diedrich A, Biaggioni I, Ray CA, Smith ML, Iwase S, Saito M, Sugiyama Y, Mano T, Zhang R, Iwasaki K, Lane LD, Buckey JC Jr, Cooke WH, Baisch FJ, Eckberg DL, Blomqvist CG; New Collective Author. Levine BD, et al. J Physiol. 2002 Jan 1;538(Pt 1):331-40. doi: 10.1113/jphysiol.2001.012575. J Physiol. 2002. PMID: 11773340 Free PMC article.

References

    1. Cox JF, et al. Journal of Physiology. 2002;538:309–320. - PMC - PubMed
    1. Ertl AC, et al. Journal of Physiology. 2002;538:321–329. - PMC - PubMed
    1. Levine BD, et al. Journal of Physiology. 2002;538:331–340. - PMC - PubMed
    1. Saltin B. Acta Physiologica Scandinavica. 1992;144(suppl 604):1–12. 13–22, 53–59, 77–87.
    1. Schondorf R, Wieling W. Clinical Autonomic Research. 2000;10:53–55. - PubMed

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