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. 2008 Sep 24;130(38):12574-5.
doi: 10.1021/ja804233g. Epub 2008 Aug 30.

Fluorescence and hybridization properties of peptide nucleic acid containing a substituted phenylpyrrolocytosine designed to engage Guanine with an additional H-bond

Filip Wojciechowski  1 , Robert H E Hudson
Affiliations

Fluorescence and hybridization properties of peptide nucleic acid containing a substituted phenylpyrrolocytosine designed to engage Guanine with an additional H-bond

Filip Wojciechowski et al. J Am Chem Soc. .

Abstract

A new pyrrolocytosine derivative has been designed to selectively interact with guanine and has been evaluated in peptide nucleic acid where it imparts increased selective binding affinity for complementary oligonucleotides. The modified nucleobase also possesses an exceptionally high fluorescence quantum yield that is responsive to hybridization.

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