Opioid circuit opens path to pain relief

Caitlynn C De Preter^{1

2}, Mary M Heinricher^{1

2}

Affiliations

¹ Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239, USA.
² Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA.

Comment

Caitlynn C De Preter et al. Science. 2024.

. 2024 Aug 30;385(6712):932-933.

doi: 10.1126/science.adr5900. Epub 2024 Aug 29.

Caitlynn C De Preter^{1

2}, Mary M Heinricher^{1

2}

¹ Department of Neurological Surgery, Oregon Health & Science University, Portland, OR 97239, USA.
² Department of Behavioral Neuroscience, Oregon Health & Science University, Portland, OR 97239, USA.

Abstract

Manipulation of neural circuits targeted by morphine enables pain relief without opioids.

Morphine-responsive neurons that regulate mechanical antinociception.
Fatt MP, Zhang MD, Kupari J, Altınkök M, Yang Y, Hu Y, Svenningsson P, Ernfors P. Fatt MP, et al. Science. 2024 Aug 30;385(6712):eado6593. doi: 10.1126/science.ado6593. Epub 2024 Aug 30. Science. 2024. PMID: 39208104 Free PMC article.