Acetofenazin
 | |
| Klinički podaci | |
|---|---|
| Drugs.com | Monografija |
| Identifikatori | |
| CAS broj | 2751-68-0  |
| ATC kod | N05AB07 (WHO) |
| PubChem | CID 17676 |
| DrugBank | DB01063 |
| ChemSpider | 16708 |
| KEGG | C06807 |
| ChEBI | CHEBI:2401 |
| ChEMBL | CHEMBL1085 |
| Hemijski podaci | |
| Formula | C23H29N3O2S |
| Molarna masa | 411,560 |
| |
| |
Acetofenazin je organsko jedinjenje, koje sadrži 23 atoma ugljenika i ima molekulsku masu od 411,560 Da.[1][2][3][4]
Osobine
[уреди | уреди извор]| Osobina | Vrednost |
|---|---|
| Broj akceptora vodonika | 6 |
| Broj donora vodonika | 1 |
| Broj rotacionih veza | 7 |
| Particioni koeficijent[5] (ALogP) | 3,2 |
| Rastvorljivost[6] (logS, log(mol/L)) | -4,0 |
| Polarna površina[7] (PSA, Å2) | 72,3 |
Reference
[уреди | уреди извор]- ^ Jones GL, Woodbury DM: Spin-label study of phenothiazine interactions with erythrocyte ghost membranes: a possible membrane-mediated antisickling action. Jones, G. L.; Woodbury, D. M. (1978 Oct). . „Spin-label study of phenothiazine interactions with erythrocyte ghost membranes: A possible membrane-mediated antisickling action”. J Pharmacol Exp Ther. 207 (1): 203—11. PMID 702341. doi:10.1016/S0022-3565(25)31408-4. Проверите вредност парамет(а)ра за датум:
|date=(помоћ) - ^ Tam SW, Cook L: Sigma opiates and certain antipsychotic drugs mutually inhibit (+)-[3H] SKF 10,047 and [3H]haloperidol binding in guinea pig brain membranes. Tam, S. William; Cook, Leonard (1984 Sep). . „σ Opiates and Certain Antipsychotic Drugs Mutually Inhibit (+)-[3H]SKF 10,047 and [3H]haloperidol Binding in Guinea Pig Brain Membranes”. Proc Natl Acad Sci U S A. 81 (17): 5618—21. Bibcode:1984PNAS...81.5618T. PMID 6147851. doi:10.1073/pnas.81.17.5618
. Проверите вредност парамет(а)ра за датум: |date=(помоћ) - ^ Knox, C.; Law, V.; Jewison, T.; Liu, P.; Ly, S.; Frolkis, A.; Pon, A.; Banco, K.; Mak, C.; Neveu, V.; Djoumbou, Y.; Eisner, R.; Guo, A. C.; Wishart, D. S. (2011). . „DrugBank 3.0: A comprehensive resource for 'Omics' research on drugs”. Nucleic Acids Research. 39 (Database issue): D1035—D1041. PMC 3013709 . PMID 21059682. doi:10.1093/nar/gkq1126.
- ^ Wishart, David S.; Knox, Craig; Guo, An Chi; Cheng, Dean; Shrivastava, Savita; Tzur, Dan; Gautam, Bijaya; Hassanali, Murtaza (2008). . „DrugBank: A knowledgebase for drugs, drug actions and drug targets”. Nucleic Acids Research. 36 (Database issue): D901—D906. PMC 2238889 . PMID 18048412. doi:10.1093/nar/gkm958.
- ^ Ghose, Arup K.; Viswanadhan, Vellarkad N.; Wendoloski, John J. (1998). . „Prediction of Hydrophobic (Lipophilic) Properties of Small Organic Molecules Using Fragmental Methods: An Analysis of ALOGP and CLOGP Methods”. The Journal of Physical Chemistry A. 102 (21): 3762—3772. Bibcode:1998JPCA..102.3762G. doi:10.1021/jp980230o.
- ^ Tetko, Igor V.; Tanchuk, Vsevolod Yu.; Kasheva, Tamara N.; Villa, Alessandro E. P. (2001). . „Estimation of Aqueous Solubility of Chemical Compounds Using E-State Indices”. Journal of Chemical Information and Computer Sciences. 41 (6): 1488—1493. PMID 11749573. doi:10.1021/ci000392t.
- ^ Ertl, Peter; Rohde, Bernhard; Selzer, Paul (2000). . „Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties”. Journal of Medicinal Chemistry. 43 (20): 3714—3717. PMID 11020286. doi:10.1021/jm000942e.
Literatura
[уреди | уреди извор]- Hardman JG, Limbird LE, Gilman AG (2001). Goodman & Gilman's The Pharmacological Basis of Therapeutics (10. изд.). New York: McGraw-Hill. ISBN 0071354697. doi:10.1036/0071422803.
- Thomas L. Lemke; David A. Williams, ур. (2007). Foye's Principles of Medicinal Chemistry (6. изд.). Baltimore: Lippincott Willams & Wilkins. ISBN 0781768799.
Spoljašnje veze
[уреди | уреди извор]
 | Molimo Vas, obratite pažnju na važno upozorenje u vezi sa temama iz oblasti medicine (zdravlja). |
