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UCD0168

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UCD0168
Clinical data
Other namesUCD-0168
Drug classSerotonin releasing agent
ATC code
  • None
Identifiers
  • 1-methyl-3-((1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-2-en-3-yl)-1H-indole
ChemSpider
Chemical and physical data
FormulaC17H20N2
Molar mass252.361 g·mol−1
3D model (JSmol)
  • CN1C=C(C2=C[C@@H](CC3)N(C)[C@@H]3C2)C4=C1C=CC=C4
  • InChI=1S/C17H20N2/c1-18-11-16(15-5-3-4-6-17(15)18)12-9-13-7-8-14(10-12)19(13)2/h3-6,9,11,13-14H,7-8,10H2,1-2H3/t13-,14+/m1/s1
  • Key:BBKRJDONOLKJBG-KGLIPLIRSA-N

UCD0168 is a serotonin releasing agent (SRA) of the tropane family related to the tryptamines.[1] It is potent, selective, and shows full efficacy as an SRA in serotonin transporter (SERT)-transfected HEK293T cells.[1] This includes selectivity for the SERT over the dopamine transporter (DAT) and norepinephrine transporter (NET).[1] However, the drug also shows substantial interaction with the serotonin 5-HT3 receptor and the sigma σ1 and σ2 receptor (92.5–95.1% binding inhibition, relative to 94.9% at the SERT).[1] The chemical synthesis of UCD0168 has been described.[1] Analogues of UCD0168 have been described, for instance UCD0820, which is a poorly selective SRA with partial releasing efficacy.[1] UCD0168 was first described in the scientific literature by David E. Olson and colleagues at the University of California, Davis (UCD) in 2025.[1]

References

[edit]
  1. 1 2 3 4 5 6 7 Avanes AA, Warren HT, Senthil A, Olson DE (September 2025). "Pharmacological Evaluation of Tropane Analogues at the Serotonin Transporter". ACS Chemical Neuroscience. 16 (17): 3354–3363. doi:10.1021/acschemneuro.5c00443. PMC 12398706. PMID 40802711.
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