PDE9

Phosphodiesterase type 9 (PDE9) is a type of phosphodiesterase enzyme.

Some inhibitors include BAY 73-6691,^[1] PF-04447943, and paraxanthine.^[2]

References

↑ Shao, Yong-xian; Huang, Manna; Cui, Wenjun; Feng, Ling-Jun; Wu, Yinuo; Cai, Yinghong; Li, Zhe; Zhu, Xinhai; Liu, Peiqing; Wan, Yiqian; Ke, Hengming; Luo, Hai-Bin (2014-12-26). "Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent". Journal of Medicinal Chemistry. 57 (24): 10304–10313. doi:10.1021/jm500836h. ISSN 1520-4804. PMC 4281101. PMID 25432025.
↑ "Paraxanthine product information" (PDF). Cayman Chemical. 2025-03-27. Archived (PDF) from the original on 2026-03-05.

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[1] Shao, Yong-xian; Huang, Manna; Cui, Wenjun; Feng, Ling-Jun; Wu, Yinuo; Cai, Yinghong; Li, Zhe; Zhu, Xinhai; Liu, Peiqing; Wan, Yiqian; Ke, Hengming; Luo, Hai-Bin (2014-12-26). "Discovery of a phosphodiesterase 9A inhibitor as a potential hypoglycemic agent". Journal of Medicinal Chemistry. 57 (24): 10304–10313. doi:10.1021/jm500836h. ISSN 1520-4804. PMC 4281101. PMID 25432025.

[2] "Paraxanthine product information" (PDF). Cayman Chemical. 2025-03-27. Archived (PDF) from the original on 2026-03-05.

[1]

[2]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

v t e Phosphodiesterase inhibitors
PDE1	MMPX SCH-51866 Vinpocetine
PDE2	BAY 60-7550 Carbazeran EHNA Oxindole PDP
PDE3	Adibendan Amrinone (inamrinone) Anagrelide Benafentrine Bucladesine Carbazeran Cilostamide Cilostazol Enoximone Ensifentrine Imazodan KMUP-1 Meribendan Milrinone Olprinone Parogrelil Pimobendan Pumafentrine Quazinone RPL-554 Siguazodan Trequinsin Vesnarinone Zardaverine
PDE4	Apremilast Arofylline Atizoram Benafentrine Catramilast CC-1088 CDP-840 CGH-2466 Cilomilast Cipamfylline Crisaborole Denbutylline Difamilast Drotaverine Ensifentrine Etazolate Filaminast Glaucine HT-0712 ICI-63197 Indimilast Irsogladine Lavamilast Lirimilast Lotamilast Luteolin Mesembrenone Mesembrine Mesopram Oglemilast Piclamilast Pumafentrine Revamilast Ro 20-1724 Roflumilast Rolipram Ronomilast RPL-554 RS-25344 Tetomilast Tofimilast YM-976 Zardaverine
PDE5	Acetildenafil Aildenafil Avanafil Beminafil Benzamidenafil Dasantafil Icariin Gisadenafil Homosildenafil Lodenafil Mirodenafil MY-5445 Nitrosoprodenafil Norcarbodenafil SCH-51866 Sildenafil Sulfoaildenafil T-0156 Tadalafil Udenafil Vardenafil
PDE7	BRL-50481
PDE9	BAY 73-6691 PF-04447943 Paraxanthine
PDE10	Balipodect Gemlapodect Mardepodect MK-8189 Papaverine TC-E 5005 Tofisopam
PDE11	BC11-38
Non-selective	Aminophylline Caffeine Choline theophyllinate CPX Dipyridamole Doxofylline Enprofylline Ibudilast IBMX Luteolin Pentoxifylline Propentofylline Theobromine Theophylline Zaprinast
Unsorted	Diazepam Diprophylline DPCPX Furafylline Lisofylline MDL-12330A Moxaverine Oxagrelate Pentifylline Proxyphylline Quercetin Satigrel Tolafentrine Trapidil
See also: Receptor/signaling modulators