Frontiers in Genetics

Original Research

Published on 03 Jul 2026

CNNKSCEC: a deep learning-based framework for chromatin loop prediction with multi-source feature integration

in Computational Genomics

Junfeng Wang
Bingzi Zheng
Lili Wu
Xiaoyan Liu
Haixia Zhai
Junwei Luo

Frontiers in Genetics

doi 10.3389/fgene.2026.1850219

267 views

Original Research

Published on 03 Jul 2026

Identification of potential biomarkers and therapeutic targets for osteoarthritis associated with arginine and proline metabolism based on transcriptome sequencing and bioinformatics

in Epigenetics and Genome Architecture

Xiao-Hua Chen
Jun Liu
Ling Qiu
Yang Zhan
Zhuo-Ming Zheng
Peng Chen
You-Xin Su
Jie-Mei Guo
Sheng-Jian Weng

Frontiers in Genetics

doi 10.3389/fgene.2026.1795267

208 views

Original Research

Accepted on 02 Jul 2026

Integrated Genetic Identification and Molecular Dynamics Simulations in a Novel LOXL3 Genetic Mutation Associated with Stickler Syndrome

in Genetics of Common and Rare Diseases

Min Ye
Shuai Li
Rui Li
Wen Zhang
Xianglian He
Lijun Ma
Qian Li
Wenjuan Zhuang

Frontiers in Genetics

Case Report

Accepted on 02 Jul 2026

A rare AGXT pathogenic variant associated with young-adult-onset end-stage kidney disease

in Human and Medical Genomics

Hui Jiang
Fuzhen Wang
Senqing Lin
Senchao Wu
Qiu Xiuping
Jinxiu Deng

Frontiers in Genetics

Correction

Accepted on 02 Jul 2026

Distribution of CYP2C19 genetic polymorphisms and pharmacogenetic implications in 11,710 cardiovascular patients: a large population-based study in eastern China

in Applied Genetic Epidemiology

Minfei Peng
Minmin He
Ying Chen
Xiaoli Zhu
Jun Li

Frontiers in Genetics

Original Research

Accepted on 02 Jul 2026

A workshop considering genetic research and data collection with American Indian and Alaska Native people outside of Tribal jurisdiction

in ELSI in Science and Genetics

Julie A Beans
Jessica Blanchard
Vanessa Y Hiratsuka
Taiawigi Helton
Stephanie Carroll
Denise Dillard
Raymond Orr
Francine Gachupin
Sara Chandros Hull
Rodney C Haring

Frontiers in Genetics

Original Research

Accepted on 02 Jul 2026

A reproducible pretreatment mucosal inflammatory-remodeling state is associated with induction-phase anti-TNF nonresponse in ulcerative colitis

in Computational Genomics

HongWei Zheng
Xin Zhuang
Wenbiao Chen

Frontiers in Genetics

Case Report

Published on 02 Jul 2026

Case Report: Novel homozygous pathogenic variant of the SPG20 gene causes the Troyer syndrome in China

in Genetics of Common and Rare Diseases

Lina Zhu
Siqi Hu
Xinyang Jiang
Rujie Gu
Yongxia Wang
Shufang Zhang
Fujun Peng
Xiuwei Ma

Frontiers in Genetics

doi 10.3389/fgene.2026.1842902

571 views

Case Report

Published on 02 Jul 2026

Homozygous familial hypercholesterolemia, experience with Evinacumab treatment in two Mexican pediatric patients: case report

in Genetics of Common and Rare Diseases

Ramón Madriz Prado
Yazmín Guadalupe Ríos Solís
Diana Estefanía Guerrero Dávila
Lucía Molina Fernández
Omar Spencer Aguilar Reyes
Ilse Ordóñez
Leticia Ramos
Marisol González

Frontiers in Genetics

doi 10.3389/fgene.2026.1841116

685 views

Original Research

Published on 02 Jul 2026

Integrative serum metabolite prioritization and functional screening identify N-acetyl-L-glutamine as a protective candidate in premature ovarian insufficiency

in Genetics of Aging

Xinyue Zhang
Chen Chen
Xiaolan Zhu

Frontiers in Genetics

doi 10.3389/fgene.2026.1827858

352 views

Original Research

Published on 02 Jul 2026

S100A9 as a shared biomarker and mediator of metabolic dysfunction in peripheral artery disease and sarcopenia

in Human and Medical Genomics

Yaming Guo
Wenxin Zhao
Hai Feng
Yongjun Li

Frontiers in Genetics

doi 10.3389/fgene.2026.1874960

422 views

Original Research

Published on 02 Jul 2026

Disease-predominant loci across Alzheimer’s disease, Parkinson’s disease and Lewy body dementia: evidence from the UK Biobank prospective cohort, conditional GWAS and colocalization

in Applied Genetic Epidemiology

Ying Zhang
Zhishuai Zhang
Shizheng Qiu
Yang Hu

Frontiers in Genetics

doi 10.3389/fgene.2026.1865257

421 views

Original Research

Published on 02 Jul 2026

Application of acute myocardial infarction-related key genes in noninvasive diagnosis: a comprehensive analysis based on transcriptome and single-cell transcriptome

in Human and Medical Genomics

Mingbin Xie
Yuanhong Wu
Xinyao Jin
Fengchun Jiang
Qiang Yao

Frontiers in Genetics

doi 10.3389/fgene.2026.1828693

315 views

Original Research

Published on 02 Jul 2026

Novel deep intronic variants in NTRK1 underlying congenital insensitivity to pain with anhidrosis

in Genetics of Common and Rare Diseases

Xin Chen
Shuang Li
Zhe Liu
Jian Cheng
Xiuzhi Ren
Xiuli Zhao

Frontiers in Genetics

doi 10.3389/fgene.2026.1852317

458 views

Original Research

Accepted on 01 Jul 2026

Gene by environment interaction effects on the metabolic subtype of Polycystic Ovary Syndrome in Hispanic Community Health Study/Study of Latinos

in Applied Genetic Epidemiology

Hridya Rao Gardner
Michelle Meyer
Jennifer Kristin Wagner
Krista Perreira
Laura Zhou
Martha Daviglus
Christina Cordero
Anne E Justice
Lindsay Fernandez-Rhodes

Frontiers in Genetics

Original Research

Published on 01 Jul 2026

Integrative bioinformatics and in vivo validation suggest a potential role of Cbr4 in alcohol use disorder through modulation of lipid metabolism and treg cell function in the central amygdala

in Behavioral and Psychiatric Genetics

Yao Ge
Yihan Yuan
Min Li
Zhenxia Huang
Chenli Zhang
Caiyu Yu
Jinyu Xu
Siao Zhang
Hongwei Guo
Xu Zhang

Frontiers in Genetics

doi 10.3389/fgene.2026.1829878

477 views

Original Research

Published on 01 Jul 2026

Clinical and neuropsychological profile of Alzheimer’s disease in Tunisia and the impact of APOE gene

in Neurogenomics

Alya Gharbi
Ikram Sghaier
Mohamed El Habibi
Youssef Abida
Amira Souissi
Amal Atrous
Meriem Zantour
Imen Kacem
Amina Gargouri Berrechid
Mouna Ben Djebara

Frontiers in Genetics

doi 10.3389/fgene.2026.1831886

577 views

Opinion

Accepted on 30 Jun 2026

Repositioning Candidate Gene Approaches in the Post-GWAS Era: A Clinical Perspective from Psychiatric Pharmacogenetics

in Pharmacogenetics and Pharmacogenomics

Milica Pjevac
Vita Dolzan
Jurij Bon

Frontiers in Genetics

147 views

Original Research

Accepted on 30 Jun 2026

CENPM as a biomarker and therapeutic target for lymph node metastasis in thyroid carcinoma

in Cancer Genetics and Oncogenomics

Ligong Zhang
Bing Wang
Mingliang Zhang

Frontiers in Genetics

Original Research

Accepted on 30 Jun 2026

Genome-wide Cis-Expression-Quantitative Trait Loci (eQTL) and Transcriptomic Signals Reveal Distinct Molecular Regulation Across Correlated Feed Efficiency Traits

in Livestock Genomics

Steffimol Rose Chacko Kaitholil
Mark H. Mooney
Omar Cristobal Carballo
Sevda Hosseinzadeh
Faisal I Rezwan
Aurelie Aubry
Masoud Shirali

Frontiers in Genetics

Original Research

Accepted on 30 Jun 2026

Carrier Frequency of Autosomal Recessive Monogenic Disorders in the Peruvian Population

in Human and Medical Genomics

Hugo Abarca Barriga
Flor Vasquez Sotomayor
Renzo Punil Luciano

Frontiers in Genetics

Original Research

Published on 30 Jun 2026

Integrated hearing and genetic screening for neonatal deafness in a resource-limited region: insights from Qingyuan, China

in Genetics of Common and Rare Diseases

Qin She
Hui-Lin Ou
Er-Fang Tang
Wei Huang
Wei-He Tan
Mu-Lan Zeng
Xiu-Feng Pan
Chen-Bing Liu

Frontiers in Genetics

doi 10.3389/fgene.2026.1873535

403 views

Case Report

Published on 30 Jun 2026

Case report: Characterization of a patient with novel biallelic variants in GTF3C3 and comprehensive review of previously reported cases

in Human and Medical Genomics

Lucía López-López
Beatriz González Giráldez
Yolanda Benítez
Belén Benavides
Carmen Ayuso
Pablo Mínguez
Fiona Blanco-Kelly
Berta Almoguera

Frontiers in Genetics

doi 10.3389/fgene.2026.1860633

392 views

Review

Published on 30 Jun 2026

Single-cell transcriptomic insights into the intrinsic cardiac nervous system: diversity, development, and neuro-cardiac interactions

in Human and Medical Genomics

Jihao Zheng
Ruotong Wu
Chujiao Gu
Changsheng Chen
Linsheng Shi

Frontiers in Genetics

doi 10.3389/fgene.2026.1833404

283 views

16,943 articles

articles

CNNKSCEC: a deep learning-based framework for chromatin loop prediction with multi-source feature integration

Identification of potential biomarkers and therapeutic targets for osteoarthritis associated with arginine and proline metabolism based on transcriptome sequencing and bioinformatics

Integrated Genetic Identification and Molecular Dynamics Simulations in a Novel LOXL3 Genetic Mutation Associated with Stickler Syndrome

A rare AGXT pathogenic variant associated with young-adult-onset end-stage kidney disease

Distribution of CYP2C19 genetic polymorphisms and pharmacogenetic implications in 11,710 cardiovascular patients: a large population-based study in eastern China

A workshop considering genetic research and data collection with American Indian and Alaska Native people outside of Tribal jurisdiction

A reproducible pretreatment mucosal inflammatory-remodeling state is associated with induction-phase anti-TNF nonresponse in ulcerative colitis

Case Report: Novel homozygous pathogenic variant of the SPG20 gene causes the Troyer syndrome in China

Homozygous familial hypercholesterolemia, experience with Evinacumab treatment in two Mexican pediatric patients: case report

Integrative serum metabolite prioritization and functional screening identify N-acetyl-L-glutamine as a protective candidate in premature ovarian insufficiency

S100A9 as a shared biomarker and mediator of metabolic dysfunction in peripheral artery disease and sarcopenia

Disease-predominant loci across Alzheimer’s disease, Parkinson’s disease and Lewy body dementia: evidence from the UK Biobank prospective cohort, conditional GWAS and colocalization

Application of acute myocardial infarction-related key genes in noninvasive diagnosis: a comprehensive analysis based on transcriptome and single-cell transcriptome

Novel deep intronic variants in NTRK1 underlying congenital insensitivity to pain with anhidrosis

Gene by environment interaction effects on the metabolic subtype of Polycystic Ovary Syndrome in Hispanic Community Health Study/Study of Latinos

Integrative bioinformatics and in vivo validation suggest a potential role of Cbr4 in alcohol use disorder through modulation of lipid metabolism and treg cell function in the central amygdala

Clinical and neuropsychological profile of Alzheimer’s disease in Tunisia and the impact of APOE gene

Repositioning Candidate Gene Approaches in the Post-GWAS Era: A Clinical Perspective from Psychiatric Pharmacogenetics

CENPM as a biomarker and therapeutic target for lymph node metastasis in thyroid carcinoma

Genome-wide Cis-Expression-Quantitative Trait Loci (eQTL) and Transcriptomic Signals Reveal Distinct Molecular Regulation Across Correlated Feed Efficiency Traits

Carrier Frequency of Autosomal Recessive Monogenic Disorders in the Peruvian Population

Integrated hearing and genetic screening for neonatal deafness in a resource-limited region: insights from Qingyuan, China

Case report: Characterization of a patient with novel biallelic variants in GTF3C3 and comprehensive review of previously reported cases

Single-cell transcriptomic insights into the intrinsic cardiac nervous system: diversity, development, and neuro-cardiac interactions