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Mefenorex

From Wikipedia, the free encyclopedia

Mefenorex
Clinical data
Trade namesRondimen, Pondinil, Anexate
Other namesN-(3-Chloropropyl)amphetamine
ATC code
Legal status
Legal status
Identifiers
  • 3-chloro-N-(1-methyl-2-phenylethyl)propan-1-amine
CAS Number
PubChem CID
ChemSpider
UNII
KEGG
CompTox Dashboard (EPA)
ECHA InfoCard100.037.511 Edit this at Wikidata
Chemical and physical data
FormulaC12H18ClN
Molar mass211.73 g·mol−1
3D model (JSmol)
  • ClCCCNC(Cc1ccccc1)C
  • InChI=1S/C12H18ClN/c1-11(14-9-5-8-13)10-12-6-3-2-4-7-12/h2-4,6-7,11,14H,5,8-10H2,1H3 checkY
  • Key:XXVROGAVTTXONC-UHFFFAOYSA-N checkY
  (verify)

Mefenorex (marketed as Rondimen, Pondinil, Anexate), also known as N-(3-chloropropyl)amphetamine, is an amphetamine derivative with a relatively mild psychostimulant profile. Developed in the 1960s, it was used throughout the 1970s as an appetite suppressant for treating obesity.[2][3] Mefenorex is a prodrug of amphetamine; upon ingestion, the compound will begin to metabolize into, as well as promote the production of, the active metabolites levoamphetamine and dextroamphetamine.[4] Multiple sources have noted the substance as exerting "mild stimulant effects....[and having] relatively little abuse potential."[5]

See also

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References

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  1. ↑ Anvisa (31 March 2023). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 4 April 2023). Archived from the original on 3 August 2023. Retrieved 16 August 2023.
  2. ↑ Vincendeau MJ (1970). "[A new regulator of appetite: mefenorex]". Bordeaux Medical (in French). 3 (7): 1951–3. PMID 5455004.
  3. ↑ Beyer G, Huth K, Müller GM, Niemöller H, Raisp I, Vorberg G (February 1980). "[The treatment of obesity with the appetite curbing agent Mefenorex]". Die Medizinische Welt (in German). 31 (8): 306–9. PMID 7374423.
  4. ↑ Rendić S, Slavica M, Medić-Sarić M (1994). "Urinary excretion and metabolism of orally administered mefenorex". European Journal of Drug Metabolism and Pharmacokinetics. 19 (2): 107–17. doi:10.1007/BF03188831. PMID 8001591. S2CID 7170057.
  5. ↑ Engel J, Kristen G, Schaefer A, von Schlichtegroll A (June 1986). "Mefenorex (Rondimen)". Drug and Alcohol Dependence. 17 (2–3): 229–34. doi:10.1016/0376-8716(86)90010-4. PMID 3743406.
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